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  1. ...opposite scenarios by quantifying the association between defense systems, MGE abundance, and gene acquisition rates in a phylogeny-aware comparative study of 197 prokaryotic species.Our results shed light on previous, apparently contradictory findings concerning the effect of CRISPR-Cas on evolution...
  2. ...Reconstructing ancestral gene content by coevolution Tamir Tuller 1 , 2 , 3 , 4 , 5 , Hadas Birin 1 , 4 , Uri Gophna 2 , Martin Kupiec 2 and Eytan Ruppin 1 , 3 1 School of Computer Sciences, Tel Aviv University...
  3. ...-existing Chromoviridae-related Gypsy clades independently expanded in different truffle lineages, leading to increased size and high gene-family turnover rates, but without resulting in highly rearranged s. Additionally, we uncover a significant enrichment of ECM-induced gene families stemming from ancestral duplication...
  4. ...islands) were identified by the values of FST and Da (Fig. 4B, gray bar; Supplemental Fig. S9). In these islands, we identified multiple genes or gene families related to host adaptation (for the longest 14 chromosomes, see Fig. 4B; Supplemental Table S7) such as the ABCC4 transporter on M17 that was also...
  5. ...features of the pig mobilome that contained 490,480 transposable element insertion polymorphisms (TIPs) resulting from recent mobilization of 970 TE families, and investigated their population dynamics along with influences on population differentiation and gene expression. In addition, several candidate...
  6. ...order of insects. Here we analyze an extensive data set of high-quality s to characterize the number and organization of all homeobox genes in 123 species of Lepidoptera from 23 taxonomic families. We find most Lepidoptera have around 100 homeobox loci, including an unusual Hox gene cluster in which...
  7. ..., and the “expansion regions,” which vary in sequence and account for most of the length differences among eukaryotic and prokaryotic rRNA genes ( Clark et al. 1984 ; Hassouna et al. 1984 ). Figure 2 plots the sequence differences among the 12 species (vertical lines). The expansion regions (white boxes) contained...
  8. ...by epistasis between residues. In prokaryotes, evolutionary innovation frequently happens by macrogenomic events such as horizontal gene transfer (HGT). Previous work has suggested that HGT can be influenced by ancestral genomic content, yet the extent of such gene-level constraints has not yet been...
  9. ...) by ( Lynch and Conery 2000 ), were overestimated by ∼100-fold because of the prevalence of gene conversion. In general, gene family loss and concomitant loss of coregulated genes characterizes eukaryotes ( Koonin et al. 2004 , and citations therein). The tetraploidies that decorate the eukaryotic...
  10. ...of bias. However, we found the same patterns of ERC presented above when we restricted analysis to only genes whose orthologs were found in all 18 species (data not shown). Evolutionary rate covariation is uniformly distributed over the protein primary sequence If intermolecular coevolution contributes...
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