Searching journal content for articles similar to Contreras Castillo et al. 31 (8): 1381.

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  1. ...and apologize for any confusion this may have caused.doi: 10.1101/gr.280860.125 Published by Cold Spring Harbor Laboratory Press Corrigendum: Characterization of DNA methylation reader proteins in Arabidopsis thaliana Jonathan Cahn , James P.B. Lloyd , Ino D. Karemaker , Pascal W.T.C. Jansen , Jahnvi Pflueger...
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  2. ...author: ryan.lister@uwa.edu.auAbstractIn plants, cytosine DNA methylation (mC) is largely associated with transcriptional repression of transposable elements, but it can also be found in the body of expressed genes, referred to as gene body methylation (gbM). gbM is correlated with ubiquitously expressed...
  3. ...to the transcription machinery. As a result, transcription levels can undergo repression leading to a silencing effect of the associated gene. The dominant form of DNA methylation in terminally differentiated human cells occurs proximal to a guanosine residue, and the resulting loci are often referred to as CpG sites...
  4. ...) dichloride (CPT), hydrogen peroxide (HP), methyl methanesulfonate (MMS), ionizing radiation (IR), and hydroxyurea (HU). Treatment conditions were determined either by establishment of EC50 or based on previous DNA damage studies of Tetrahymena (Supplemental Table S1; Campbell and Romero 1998; Loidl...
  5. ...independent of copy number changes; these processes increase the tumor mutation burden and thus the likelihood of novel driver mutations. Mutations arise through impairments in DNA-damage repair pathways (Wu et al. 2020), endogenous processes including APOBEC mutagenesis, and exogenous factors such as smoking...
  6. ..., Pennsylvania 19104, USA Corresponding authors: montanoc@chop.edu, wtimp@jhu.eduAbstractIn this mini-review, we explore the advancements in -wide DNA methylation profiling, tracing the evolution from traditional methods such as methylation arrays and whole- bisulfite sequencing to the cutting-edge single...
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  7. ...genes with dosage sensitivity to the Y number are shown. Pearson's correlation coefficient (R), P-value, and FDR are indicated.The presence of an extra Y Chromosome results in subtle changes in DNA methylationTo understand the impact of an extra Y Chromosome on global DNA methylation, we performed...
  8. ...as a fundamental technique for characterizing the functional state of individual cells. Complementary to scRNAseq, single-cell DNA methylation (scDNAm) sequencing provides -wide maps of epigenetic modifications at single-cell resolution, offering insights into the regulatory mechanisms underlying gene expression...
  9. ...genomics. Early works in molecular biology on gene expression were limited, because purified RNA is unstable and difficult to work with. However, the discovery (and use in the laboratory) of reverse transcriptase, permitting the controlled synthesis of RNAs into cDNAs (Maniatis et al. 1976...
  10. ...is lacking.DNA methylation in the context of CG, CHG, and CHH (H = A, T, or C) can affect gene expression levels and silencing of transposons or repeat sequences, etc. Methylated cytosine is also a major source of point mutations during DNA replication (Phillips et al. 1994; Jeltsch 2010; Lu et al. 2021...
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