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Research: Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer
- Fátima Valdés-Mora,
- Jenny Z. Song,
- Aaron L. Statham,
- Dario Strbenac,
- Mark D. Robinson,
- Shalima S. Nair,
- Kate I. Patterson,
- David J. Tremethick,
- Clare Stirzaker,
- and Susan J. Clark
Genome Res. February 2012 22: 307-321; Published in Advance July 25, 2011, doi:10.1101/gr.118919.110
...expression in human cancer has not been addressed.To explore the relationship between gene expression, H2A.Z/acH2A.Z promoter occupancy, and the epigenetic repressive marks of DNA methylation and H3K27me3 in human cancer, we performed ChIP-on-chip (for histone marks) and MBDCap.seq (for DNA methylation...
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Research: TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells
- Kasper D. Rasmussen,
- Ivan Berest,
- Sandra Keβler,
- Koutarou Nishimura,
- Lucía Simón-Carrasco,
- George S. Vassiliou,
- Marianne T. Pedersen,
- Jesper Christensen,
- Judith B. Zaugg,
- and Kristian Helin
Genome Res. April 2019 29: 564-575; Published in Advance February 22, 2019, doi:10.1101/gr.239277.118
...Corresponding authors: k.d.rasmussen@dundee.ac.uk, judith.zaugg@embl.de, helink@mskcc.orgAbstractThe epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development and lead to altered DNA methylation...

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