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Research: Telomerase-independent survival leads to a mosaic of complex subtelomere rearrangements in Chlamydomonas reinhardtii
- Frédéric Chaux,
- Nicolas Agier,
- Clotilde Garrido,
- Gilles Fischer,
- Stephan Eberhard,
- and Zhou Xu
Genome Res. September 2023 33: 1582-1598; Published in Advance August 14, 2023, doi:10.1101/gr.278043.123
...these alterations are not all well understood but often involve classical and alternative nonhomologous end-joining (c- and a-NHEJ), homology-directed repair (HDR), including homologous recombination and break-induced replication (BIR), together with missegregation of chromosomes, breakage–fusion–bridge (BFB...
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Research: C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
- Bettina Meier,
- Susanna L. Cooke,
- Joerg Weiss,
- Aymeric P. Bailly,
- Ludmil B. Alexandrov,
- John Marshall,
- Keiran Raine,
- Mark Maddison,
- Elizabeth Anderson,
- Michael R. Stratton,
- Anton Gartner,
- and Peter J. Campbell
Genome Res. October 2014 24: 1624-1636; Published in Advance July 16, 2014, doi:10.1101/gr.175547.114
...to errors and yet necessary for cellular survival. These include nonhomologous DNA end-joining (NHEJ), a repair modality that leads to direct ligation of broken DNA ends, and translesion synthesis (TLS), a process where error-prone polymerasesmaintain replication opposite damaged DNA bases (for review, see...
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