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  1. ...such as compaction and accessibility, whereas endogenous DNA allows for in cellulo analysis under physiological conditions. Similarly, proteins can be purified and studied in vitro, expressed exogenously from a plasmid, or endogenously produced within the cell from genomic DNA. Although plasmid-based expression...
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  2. ...was applied. (E) Genomic locations of detected tags. Tag counts were normalized using the DESeq2 median-of-ratios approach using a threshold of n = 3 counts.Multiple steps of the TSS-seq protocol were optimized, including fragmentation, reverse transcription, RNA clean-up, PCR, and DNA size selection...
  3. ...Barcelona, Spain Corresponding authors: claudia.carareto@unesp.br, cristina.vieira@univ.lyon1.frAbstractHost shifts in insects are considered a key process with the potential to contribute to reproductive isolation and speciation. Both genomic and transcriptomic variation are attributed to such a process...
  4. ...-inspired ConvNeXt V2 blocks, originally designed for vision tasks but well-suited for capturing local and global genomic features (Woo et al. 2023) (Fig. 1C,D).Previous studies have shown that transformer architectures can outperform convolution-based models in capturing long-range dependencies in genomic...
  5. ...6BT, United Kingdom; 2Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom; 3Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, United Kingdom; 4University College London Cancer...
  6. ...Pan analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility Dongying Xie1,2,3, Pohao Ye1,3, Yiming Ma1 and Zhongying Zhao1 1Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China; 2Institute for Research...
  7. ...1, Raony Cardenas1, Thyago Cardoso1, Luis F. Paulin2, Philippe Sanio2, Joseph Mafofo1, Haiguo Wu1, Val Zvereff1, Albarah El-Khani1, Fahed Al Marzooqi1, Tiago R. Magalhães1, Fritz J. Sedlazeck2,3,4 and Javier Quilez1 1M42, Abu Dhabi, United Arab Emirates; 2Human Genome Sequencing Center, Baylor...
  8. ...Sistemas Informáticos, Programa de Doctorado en Software. ↵Treangen TJ, Ondov BD, Koren S, Phillippy AM. 2014. The Harvest suite for rapid core- alignment and visualization of thousands of intraspecific microbial s. Genome Biol 15: 524. doi:10.1186/s13059-014-0524-x ↵Yoo D, Rhie A, Hebbar P, Antonacci F...
  9. ...non-human species. For each human sSNV, SynMall provides multilevel annotations that combine American College of Medical Genetics and Genomics (ACMG)–aligned variant interpretation information, such as allele frequencies and functional effects, with more than 100 descriptors at the DNA, RNA...
  10. ...disease data. However, we also want to show that adding single-cell data from diseased individuals to the reference can help improve its accuracy at classifying query cells and consequently query individuals. We can change the cell classification step in scPSS to be better suited to this (weakly...
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