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  1. ...with meiotic catastrophe and infertility (Zamudio et al. 2015). In contrast, A. thaliana H3K9me2 and DNA methylation mutants are fully fertile, despite increased recombination initiation in the centromeric regions, suggesting that increased meiotic DSBs in transposons do not, per se, cause infertility...
  2. ...and promote strand invasion of homologous DNA (Hunter 2015). In plants and mammals, a minority of strand invasion events mature into crossovers (∼3%–10% of DSBs) (Cole et al. 2010; Mercier et al. 2015), with most dissociated via anticrossover pathways (Hunter 2015).Meiotic recombination is orchestrated...
  3. ...recent emergence, presumably as an outcome of meiotic drive. We also analyzed the nucleolus organizer region (NOR), which contains megabase-scale arrays of rDNA (Fig. 3C; Supplemental Fig. S16). All-by-all alignment of the 6S knob linked to the NOR indicated three distinct clusters with progressive...
  4. ...reduce the impact of such positional flexibility.An intriguing feature of the DNA methylation patterns in active human centromeres is a hypomethylated region, known as the centromeric dip region, within a hypermethylated HOR that is occupied by CENPA (Gershman et al. 2022). The hypomethylated regions...
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  5. ..., and the remainder roots from the other inbred parent. These AR genes also may result from large-scale DNA repair, nonallelic end-joining, or even transposon activity (Wang et al. 2006; Levin and Moran 2011; Bao and Yan 2012; Fedoroff 2012; Liu et al. 2016). The aforementioned mechanisms may lead to allelic...
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