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  1. ...a cluster on the right arm of Chr IV (Fig. 6B). Although the genomic regions surrounding this gene cluster show lower conservation (i.e., reduced phyloP scores) than those flanking Cni-neib-1, the syntenic genes bordering both regions remain conserved (Fig. 6B). This conservation suggests that the fbxn...
  2. ...and the amount of genomic convergence. To our knowledge, we so far lacked study designs that could quantify genomic convergence accounting for both species relatedness and age of transition.Rodentia is the most diversified order of mammals with living representatives spanning 70 million years (MY) of evolution...
  3. ...in the retrieval of the Hox C cluster, an array of homeobox-containing genes (for review, see Kuraku 2021). While their Hox A, B, and D gene clusters have been reliably assembled with few gaps (Mulley et al. 2009; Hara et al. 2018), assembling the Hox C cluster, which was initially reported as missing from...
  4. ...) Heat map illustrating the distribution of features across clustered samples. The x-axis corresponds to the 500 samples, and the y-axis denotes the features. (E) Characteristic attributes in SHAP are represented on a beeswarm plot, with each line corresponding to a specific SNP feature. Genotypes...
  5. ...IP-seq data sets from the Cistrome Data Browser (Taing et al. 2024), covering a range of conditions (estrogen-depleted, E2-treated, full-medium), and overlapped them with our ERBS categories. Unsupervised clustering confirmed that only active histone modifications overlapped ERBS, with a notable enrichment...
  6. ...Stenocereus gummosus, and D. m. sonorensis is also a columnar cacti dweller, using Stenocereus thurberi (Newby and Etges 1998). Therefore, this set of species from the buzzatii and mojavensis clusters provides an excellent model to investigate the molecular mechanisms underlying host shift evolution...
  7. ...function. Mutations are analyzed using paralogs grouped into functional families with highly similar functions, identifying 355 functional impact events (FIEs) through their proximity and clustering near to functional sites. The use of functional family paralogs to map mutations to protein structures from...
  8. ...exhibit 532 heterogeneous distribution patterns, with some, such as finTRIMs, in gene groups dispersed 533 across the while others, including MHC class I genes, form a few or a unique cluster 534 on a specific location (Van der Aa et al., 2009; Lukacs et al., 2010). These findings 535 underscore...
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  9. ...of the fifth carbon atom of cytosine, typically in mammals in a CG dinucleotide context. This dinucleotide is depleted largely across the and found predominantly in clusters known as “CpG islands” (Bird 1986). Cytosine methylation is catalyzed by methyltransferases (e.g., DNMT1, DNMT3A) that transfer a methyl...
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  10. ...score and fragment count in the ATACmodality using SnapATAC2 (Zhang et al. 2024a; Methods; Supplemental Fig. S1). Potential doublets were also excluded, resulting in 40,125 highquality cells retained for further analysis. Next, we performed iterative clustering using the RNA modality and integrated...
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