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LETTER: Genome-wide prediction of G4 DNA as regulatory motifs: Role in Escherichia coli global regulation
- Pooja Rawal,
- Veera Bhadra Rao Kummarasetti,
- Jinoy Ravindran,
- Nirmal Kumar,
- Kangkan Halder,
- Rakesh Sharma,
- Mitali Mukerji,
- Swapan Kumar Das,
- and Shantanu Chowdhury
Genome Res. May 2006 16: 644-655; doi:10.1101/gr.4508806
...phylogenetically distant organisms. We hypothesized a regulatory role of G4 DNA during supercoiling stress, when duplex destabilization may result in G4 formation. This is in line with our observations from target site analysis for 55 DNA-binding proteins in Escherichia coli, which reveals significant ( P &lt; 0...
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LETTER: Stress-Induced DNA Duplex Destabilization (SIDD) in the E. coli Genome: SIDD Sites Are Closely Associated With Promoters
- Huiquan Wang,
- Michiel Noordewier,
- and Craig J. Benham
Genome Res. August 2004 14: 1575-1584; doi:10.1101/gr.2080004
...to the proposal that chromosomal superhelicity may be a global regulator of gene expression in Escherichia coli ( Hatfield and Benham 2002 ). Strand separation in most DNA regulatory events is not mediated by superhelical stresses alone, but instead usually involves interactions between the DNA and other...

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