Searching journal content for articles similar to Chen et al. 24 (7): 1209.

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  1. ..., USA Abstract We report a statistical study to discover transcriptome similarity of developmental stages from D. melanogaster and C. elegans using modENCODE RNA-seq data. We focus on “stage-associated genes” that capture specific transcriptional activities in each stage and use them...
  2. ...and proteome to study translational delay We compared our embryogenesis proteome with the transcriptome generated as part of the modENCODE Project (Graveley et al. 2011). In agreement with the transcriptome analysis, we found that the general protein complexity is increased during embryogenesis (Fig. 7A...
  3. ...ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia Stephen G. Landt 1 , 26 , Georgi K. Marinov 2 , 26 , Anshul Kundaje 3 , 26 , Pouya Kheradpour 4 , Florencia Pauli 5 , Serafim Batzoglou 3 , Bradley E...
  4. ..., Baltimore, Maryland 21218, USA; 3Department of Computer Science, Johns Hopkins University, Baltimore, Maryland 21218, USA Corresponding authors: wtimp@jhu.edu, james@taylorlab.org, jnkim@jhu.eduAbstractCurrent transcriptome annotations have largely relied on short read lengths intrinsic to the most widely...
  5. ...with the region through protein–protein interactions (Moorman et al. 2006; Gerstein et al. 2010; The modENCODE Consortium 2010; Yip et al. 2012). HOT regions are also associated with histone modification profiles and chromatin signatures characteristic of open chromatin in human and D. melanogaster, with strong...
  6. ....5 Mb with four clone gaps in unsized introns. To validate the Myo81F gene structure and the assembly of the super scaffold, we mapped RNA-seq reads from the modENCODE developmental time course (Graveley et al. 2011) to the cDNA sequence. Myo81F is expressed in the larval and pupal stages, most...
  7. ..., although they are observed in mixed larva and pupa samples (Fig. 2D, ‘‘Male’’). Other clusters express most abundantly in a specific stage (Fig. 2D, ‘‘Larva’’). Figure 1. Deep RNA-seq covers 93% of the annotated D. melanogaster transcriptome. (A) 93.4% and 91.9% of the FlyBase and modENCODE annotated...
  8. ...the is sequenced. Annotation of protein-coding genes is currently based on gene prediction algorithms (Renuse et al. 2011; Megy et al. 2012; Jiang et al. 2014). The annotated genes remain as hypothetical sequences until validated through experiments. The experimental data might include transcriptomic data, which...
  9. ...downloaded the publicly available expression data generated from the D. melanogaster germline by the modENCODE project (Graveley et al. 2011) and measured the density of polymorphisms within genes that are binned by expression level (bin levels 1–8 for low-to-high expression) (see Methods). We find...
  10. ...by the Ambros, Tuschl, and Bartel groups in 2001, more than a hundred studies have sought to identify additional miRNAs in various species. We report here a meta-analysis of short RNA data from Drosophila melanogaster , aggregating published libraries with 76 data sets that we generated for the modENCODE...
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