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  1. ..., oocytes, and embryonic stem cells have shown DNA methylation (DNAm) in non-CG contexts, such as mCHG and mCHH, where H represents A, C, or T (Kinde et al. 2015). These are notably less mitotically active, presumably because such marks are more difficult to maintain with active replication...
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  2. ...-translational modifications, play a crucial role in regulating programs integral to a cell's identity, like gene expression and DNA replication. However, the transcriptional, chromatin, and replication timing profiles of adult stem cells in vivo remain poorly understood. Containing germline stem cells (GSCs) and somatic cyst...
  3. ...relatively low sensitivity.View larger version: In this window In a new window Figure 1. miRNA profiling in single mouse embryonic stem cells (mESCs) by Small-seq. (A) Number of distinct miRNAs detected in each single cell. (B) Top 25 miRNAs in mESCs. The number of detected molecules was estimated using...
  4. ...19 20 21 2 Abstract 22 Parkinson’s disease (PD) is a prevalent neurodegenerative disorder predominantly affecting 23 individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons 24 within the substantia nigra. Despite aging being a significant risk factor, the specific...
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  5. ...to Mbp, retain much longer-range genomic information. Therefore, they can more easily distinguish intra-genomic repeats or highly similar strains, which supports the disambiguation of reads when determining the strain they stem from. Second, as per the basic properties of single-molecule sequencing...
  6. ...the Pearson correlation coefficient. Subsequently, the direction of change was investigated by comparing the expression profiles of each paralog to their co-orthologous outgroup gene.When analyzing pairs of paralogs in each category, within both animals and plants, paralogs from the asymmetric category showed...
  7. ...Single-cell transcriptome and meta profiling reveals the genetic basis of rumen functions and convergent developmental patterns in ruminants Juan Deng1,2,7, Ya-Jing Liu1,7, Wen-Tian Wei1, Qi-Xuan Huang1, Li-Ping Zhao3,4, Ling-Yun Luo1, Qi Zhu2, Lin Zhang2, Yuan Chen2, Yan-Ling Ren5, Shan-Gang Jia6...
  8. ...(A.G. and C.B.), R35GM149520 (C.B.), R01GM129523 (S.H.), and National Science Foundation grant 2003358 (A.G.). We thank T. Xu and T. Dishon for their input, as well as R. Wachs for her help with the illustrations. We thank the Stem Cell Genomics Core at the Sanford Stem Cell Institute...
  9. ...Corresponding author: michael.werner@utah.eduAbstractDevelopmental plasticity enables the production of alternative phenotypes in response to different environmental conditions. Although significant advances in understanding the ecological and evolutionary implications of plasticity have been made...
  10. ...ISWI1 complex proteins facilitate developmental editing in Paramecium Aditi Singh1,5, Lilia Häußermann1,5, Christiane Emmerich1, Emily Nischwitz2, Brandon K.B. Seah1, Falk Butter2,3, Mariusz Nowacki4 and Estienne C. Swart1 1Max Planck Institute for Biology, 72076 Tübingen, Germany; 2Institute...
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