Searching journal content for articles similar to Cao et al. 33 (8): 1369.

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  1. Method: Long-read RNA sequencing reveals allele-specific N6-methyladenosine modifications
    • Dayea Park and
    • Can Cenik
    Genome Res. April 2025 35: 999-1011; Published in Advance October 29, 2024, doi:10.1101/gr.279270.124
    .... 2021). While the significance of allele-specific RNA expression is well-acknowledged, allele-specific RNA modification remains underexplored.N6-methyladenosine (m6A), the most prevalent RNA modification of mRNAs, has been suggested to impact diverse mechanisms to regulate gene expression (Lee et al...
  2. Perspective: Decrypting noncoding RNA interactions, structures, and functional networks
    • Muller Fabbri,
    • Leonard Girnita,
    • Gabriele Varani,
    • and George A. Calin
    Genome Res. September 2019 29: 1377-1388; Published in Advance August 21, 2019, doi:10.1101/gr.247239.118
    ...sequence motifs often suffice to confer specific recognition features to a ncRNA; for example, N6-methyladenosine alters RNA structure to regulate binding to low-complexity regions in RBPs (Liu et al. 2017b). However, other functional properties of the ncRNA rely on secondary and 3D structure. RNAs...
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  3. Review: Navigating the landscape of epitranscriptomics and host immunity
    • Elaine Huang,
    • Clara Frydman,
    • and Xinshu Xiao
    Genome Res. April 2024 34: 515-529; Published in Advance May 3, 2024, doi:10.1101/gr.278412.123
    ...of immunogenic RNAs, regulation of genes involved in innate immune response, and facilitation of adaptive immunity. Given extensive evidence for their immune relevance, we focus on reviewing the contributions of the following internal (non-cap) host RNA modifications: N6-methyladenosine (m6A), 5-methylcytosine...
  4. Perspective: Unraveling the hidden complexity of cancer through long-read sequencing
    • Qiuhui Li,
    • Ayse G. Keskus,
    • Justin Wagner,
    • Michal B. Izydorczyk,
    • Winston Timp,
    • Fritz J. Sedlazeck,
    • Alison P. Klein,
    • Justin M. Zook,
    • Mikhail Kolmogorov,
    • and Michael C. Schatz
    Genome Res. April 2025 35: 599-620; Published in Advance March 20, 2025, doi:10.1101/gr.280041.124
    ...exon 1 of the APC gene (Fig. 2D). RNA-seq analysis revealed a substantial decrease in APC expression in the tumor sample (tumor fragments per kilobase of transcript per million fragments mapped (FPKM): 0.296 vs. normal FPKM: 2.262). The SV was not detected by short-read sequencing, likely because...
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  5. Editorial: Long reads decipher genomes and transcriptomes and offer novel insights into biology and diseases
    • Ana Conesa,
    • Alexander Hoischen,
    • and Fritz J. Sedlazeck
    Genome Res. April 2025 35: xi-xiv; doi:10.1101/gr.280665.125
    ...transcripts. Park and Cenik (2025) leverage long-read RNA-seq to reveal allele-specific N6-methyladenosine (m6A) modifications in human and mouse cells, uncovering sequence determinants of m6A deposition. Murali et al. (2025) develop Biosurfer, a computational tool for tracking regulatory mechanisms leading...
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