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  1. ...). A summary of the interactions at promoters and enhancers is shown in Figure 7. The widespread partnership of NF-Y with a group of TFs (FOS, MYC, and E2Fs) that control cellular proliferation and play important roles in cancer are consistent with the importance of NF-Y for expression of growth...
  2. ...Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan; 5Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA Corresponding author: snamekawa@ucdavis.eduAbstractAs transposable elements (TEs) coevolved with the host , the host exploited...
  3. ...be epigenetically marked like enhancers including positioned phased nucleosomes, active histone marks including H3K4me1 and H3K27ac, enrichment upstream proximal to genes, and preferential long-range contacts with promoters (Su et al. 2014). A subset of Alu elements functions as enhancers for cell-cycle genes...
  4. .... ↵ 17 Present address: Department of Urology, General Hospital of the People's Liberation Army (PLAGH), Haidian District, 100853 Beijing, China. Abstract DNA methylation plays key roles in diverse biological processes such as X chromosome inactivation, transposable element repression, genomic...
  5. ...their transcription (Rinn et al. 2007; Gupta et al. 2010; Tsai et al. 2010), and TP53COR1 (also known as lincRNA-p21) is induced by TP53 upon DNA damage or oncogenic stress and causes the widespread suppression of numerous genes by recruiting the repressor protein HNRNPK, thereby acting as a potential tumor...
  6. ...one or more regulatory elements. Chromosomal breakpoints in the intergenic region of the two genes are opposed by selection since it would affect the coordinated expression of the two genes. (B) Genomic regulatory block (GRB): A bystander gene (green) contains regulatory elements in its introns...
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