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Research: Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis
- Mihaela Ola,
- Caoimhe E. O'Brien,
- Aisling Y. Coughlan,
- Qinxi Ma,
- Paul D. Donovan,
- Kenneth H. Wolfe,
- and Geraldine Butler
Genome Res. May 2020 30: 684-696; Published in Advance May 18, 2020, doi:10.1101/gr.257816.119
.... We report here that isolates of the pathogenic yeast species Candida parapsilosis show within-species polymorphism for the location of centromeres on two of its eight chromosomes. Its old centromeres have an inverted-repeat (IR) structure, whereas its new centromeres have no obvious structural...
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Research: New signaling pathways govern the host response to C. albicans infection in various niches
- Yaoping Liu,
- Amol C. Shetty,
- Jennifer A. Schwartz,
- L. Latey Bradford,
- Wenjie Xu,
- Qyunh T. Phan,
- Priti Kumari,
- Anup Mahurkar,
- Aaron P. Mitchell,
- Jacques Ravel,
- Claire M. Fraser,
- Scott G. Filler,
- and Vincent M. Bruno
Genome Res. May 2015 25: 679-689; Published in Advance April 9, 2015, doi:10.1101/gr.187427.114
...@ucla.edu ↵ 6 Present address: Profectus BioSciences, Baltimore, Maryland 21224-6538, USA Abstract Candida albicans , the major invasive fungal pathogen of humans, can cause both debilitating mucosal infections and fatal invasive infections. Understanding the complex nature of the host–pathogen...
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Research: Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth
- Christina A. Cuomo,
- Christopher A. Desjardins,
- Malina A. Bakowski,
- Jonathan Goldberg,
- Amy T. Ma,
- James J. Becnel,
- Elizabeth S. Didier,
- Lin Fan,
- David I. Heiman,
- Joshua Z. Levin,
- Sarah Young,
- Qiandong Zeng,
- and Emily R. Troemel
Genome Res. December 2012 22: 2478-2488; Published in Advance July 18, 2012, doi:10.1101/gr.142802.112
...only pathogens in the replicative meront stage, while later time-point samples (40 and 64 hpi) contain amixture of pathogens in themeront, sporont, and mature transmissible spore stages. In addition to microscopy, RNA-seq and qRT-PCR analysis of amixedpathogen andhost RNA sample illustrates how rapidly...

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