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  1. ...been previously coupled with microarray analysis to spatially map brain gene expression patterns in both a mouse model of Parkinson’s disease ( Brown et al. 2002b ) and a post-mortem human brain tissue to study the effects of Alzheimer’s disease ( Brown et al. 2002a ). To address the challenge...
  2. ...are also important tools for understanding andmodeling disease. InMendelian disorders, in which single gene products are implicated in disease or development, nuclease-aided disruption or deletion can be used to determine causal relationships between genes and phenotypes (Soldner et al. 2011; Toscano et al...
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