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  1. ...the formation of unfit MHC-I–APG recombinants. This theory, based on research in chicken and rat, assumes a single dominantly expressed MHC-I gene that coevolves with APGs (Kaufman 1999, 2015). Such a state has been suggested as ancestral for jawed vertebrates, with a “lucky” accident of a genomic rearrangement...
  2. ..., as some placental mammals exhibit X Chromosome rearrangements relative to the placental mammal ancestor, although these are generally more rare and phylogenetically restricted (e.g., mouse, rat) (Amar et al. 1988; Piumi et al. 1998; Robinson et al. 1998; Sandstedt and Tucker 2004; Park et al. 2013...
  3. ...-specific traits. Following completion of the human sequence, there is now considerable interest in obtaining a more comprehensive understanding of its evolution ( International Human Genome Sequencing Consortium [IHGSC] 2001 ; International Mouse Genome Sequencing Consortium [IMGSC] 2002 ; Rat Genome Sequencing...
  4. ..., macaque, mouse, rat, dog, and opossum. MGRA relies on the notion of the multiple breakpoint graphs to overcome some limitations of the existing approaches to ancestral genome reconstructions. MGRA also generates the rearrangement-based characters guiding the phylogenetic tree reconstruction when...
  5. ...–36. ↵ Bourque, G., Pevzner, P.A., and Tesler, G. 2004 . Reconstructing the genomic architecture of ancestral mammals: Lessons from human, mouse, and rat s. Genome Res. 14 : 507 –516. ↵ Bourque, G., Zdobnov, E.M., Bork, P., Pevzner, P.A., and Tesler, G. 2005 . Comparative architectures of mammalian...
  6. ...yielded very similar results, with a slight increase in R2 values. We asked whether there was a correlation between recombination rates in these mammals and the neutral mutation rate determined by the rate of substitution in ancestral repeats along each branch in the human–mouse–rat (HMR) phylogenetic...
  7. ...A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains Yongming Wang 1 , 4 , František Liška 1 , 2 , 4 , Claudia Gosele 1 , Lucie Šedová 2 , Vladimír Křen 2 , Drahomíra Křenová 2...
  8. ...those considered. 6 These numbers, normalized using the MA -human edge, are displayed in Table 2 . View larger version: In this window In a new window Figure 2. Ancestral murid rodent ancestor ( RA ), ancestral mammalian ancestor ( MA ), and evolutionary tree recovered by MGR using the human, mouse, rat...
  9. ...References ↵ Bourque, G. and Pevzner, P.A. 2002 . Genome-scale evolution: Reconstructing gene orders in the ancestral species. Genome Res. 12 : 26 –36. ↵ Bourque, G., Pevzner, P.A., and Tesler, G. 2004 . Reconstructing the genomic architecture of ancestral mammals: Lessons from human, mouse, and rat s...
  10. ....A., and Tesler, G. 2004 . Reconstructing the genomic architecture of ancestral mammals: Lessons from human, mouse, and rat s. Genome Res. 14 : 507 -516. ↵ Britton-Davidian, J., Catalan, J., da Graca Ramalhinho, M., Ganem, G., Auffray, J.C., Capela, R., Biscoito, M., Searle, J.B., and da Luz Mathias, M. 2000...
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