Searching journal content for articles similar to Bolivar et al. 11 (9): 1549.

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  1. Research: Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis
    • Soha N. Yazbek,
    • David A. Buchner,
    • Jonathan M. Geisinger,
    • Lindsay C. Burrage,
    • Sabrina H. Spiezio,
    • Gabriel E. Zentner,
    • Chang-Wen Hsieh,
    • Peter C. Scacheri,
    • Colleen M. Croniger,
    • and Joseph H. Nadeau
    Genome Res. July 2011 21: 1065-1073; Published in Advance April 19, 2011, doi:10.1101/gr.120741.111
    ...linked, phenotypically heterogeneous quantitative trait loci (QTLs) on mouse chromosome 6 that have unexpectedly large phenotypic effects. Although fine-mapping reduced the genomic intervals and gene content of these QTLs over 3000-fold, the average phenotypic effect on body weight was reduced less than...
  2. PERSPECTIVE: Genomics of the future: Identification of quantitative trait loci in the mouse
    • Lorraine Flaherty,
    • Bruce Herron,
    • and Derek Symula
    Genome Res. December 2005 15: 1741-1745; doi:10.1101/gr.3841405
    ...Genomics of the future: Identification of quantitative trait loci in the mouse Lorraine Flaherty 1 , Bruce Herron , and Derek Symula Genomics Institute, Wadsworth Center, Troy, New York 12180, USA Abstract Positional cloning...
  3. LETTER: Using Advanced Intercross Lines for High-Resolution Mapping of HDL Cholesterol Quantitative Trait Loci
    • Xiaosong Wang,
    • Isabelle Le Roy,
    • Edwige Nicodeme,
    • Renhua Li,
    • Richard Wagner,
    • Christina Petros,
    • Gary A. Churchill,
    • Stephen Harris,
    • Ariel Darvasi,
    • Jorge Kirilovsky,
    • Pierre L. Roubertoux,
    • and Beverly Paigen
    Genome Res. July 2003 13: 1654-1664; Published in Advance June 12, 2003, doi:10.1101/gr.1185803
    ...Using Advanced Intercross Lines for High-Resolution Mapping of HDL Cholesterol Quantitative Trait Loci Xiaosong Wang 1 , Isabelle Le Roy 2 , Edwige Nicodeme 3 , Renhua Li 1 , Richard Wagner 1 , Christina Petros 1 , Gary A...
  4. ARTICLE: Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 Diabetes
    • Iain A. Eaves,
    • Linda S. Wicker,
    • Ghassan Ghandour,
    • Paul A. Lyons,
    • Laurence B. Peterson,
    • John A. Todd,
    • and Richard J. Glynne
    Genome Res. February 1, 2002 12: 232-243; Published in Advance January 13, 2003, doi:10.1101/gr.214102
    ...Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 Diabetes Iain A. Eaves 1 , Linda S. Wicker 2 , 5 , Ghassan Ghandour 3 , Paul A. Lyons 1 , Laurence B. Peterson 4...
  5. LETTER: Voluntary Ethanol Consumption by Mice: Genome-Wide Analysis of Quantitative Trait Loci and Their Interactions in a C57BL/6ByJ × 129P3/J F2 Intercross
    • Alexander A. Bachmanov,
    • Danielle R. Reed,
    • Xia Li,
    • Shanru Li,
    • Gary K. Beauchamp,
    • and Michael G. Tordoff
    Genome Res. August 1, 2002 12: 1257-1268; doi:10.1101/gr.129702
    ...Voluntary Ethanol Consumption by Mice: Genome-Wide Analysis of Quantitative Trait Loci and Their Interactions in a C57BL/6ByJ × 129P3/J F2 Intercross Alexander A. Bachmanov 1 , Danielle R. Reed , Xia Li , Shanru Li , Gary K. Beauchamp...
  6. Perspective: Genetic architecture of quantitative traits in mice, flies, and humans
    • Jonathan Flint and
    • Trudy F.C. Mackay
    Genome Res. May 2009 19: 723-733; doi:10.1101/gr.086660.108
    ...of effect size of common variants is the same for all phenotypes regardless of species, and we discuss the importance of epistasis, pleiotropy, and gene by environment interactions. Despite substantial advances in mapping quantitative trait loci, the identification of the quantitative trait genes...
  7. RESEARCH: Genome Scan and Congenic Strains for Blood Pressure QTL Using Dahl Salt-Sensitive Rats
    • Michael R. Garrett,
    • Howard Dene,
    • Roxanne Walder,
    • Qian-Yun Zhang,
    • George T. Cicila,
    • Shahin Assadnia,
    • Alan Y. Deng,
    • and John P. Rapp
    Genome Res. July 1, 1998 8: 711-723; doi:10.1101/gr.8.7.711
    ...and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm. Genome 8 : 229 – 235 . ↵ Eshed Y. , Zamir D. ( 1996 ) Less-than-additive epistatic interactions of quantitative trait loci in tomato. Genetics 143 : 1807 – 1817 . ↵ Fijneman R.J.A. , de Vries S.S. , Jansen R.C. , Demant P. ( 1996...
  8. LETTER: Congenic Mapping of the Type 1 Diabetes Locus, Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping
    • Paul A. Lyons,
    • Nicola Armitage,
    • Fabio Argentina,
    • Paul Denny,
    • Natasha J. Hill,
    • Christopher J. Lord,
    • Mary Beth Wilusz,
    • Laurence B. Peterson,
    • Linda S. Wicker,
    • and John A. Todd
    Genome Res. April 1, 2000 10: 446-453; doi:10.1101/gr.10.4.446
    ...mouse has proved more tractable ( Lyons and Wicker 1999 ). A number of experimental strategies for fine mapping quantitative trait loci (QTL) in mice have been proposed (reviewed in Darvasi 1998 ). The approach we have adopted to fine map Idd loci in the NOD mouse is one based on the congenic strategy...
  9. METHODS: Multiple Cross and Inbred Strain Haplotype Mapping of Complex-Trait Candidate Genes
    • Yeong-Gwon Park,
    • Robert Clifford,
    • Kenneth H. Buetow,
    • and Kent W. Hunter
    Genome Res. January 1, 2003 13: 118-121; doi:10.1101/gr.786403
    ....J. , Rodriguez-Zas S.L. , Mogil J.S. ( 2001 ) In silico mapping of mouse quantitative trait loci. Science 294 : 2423 . ↵ Cozma D. , Lukes L. , Rouse J. , Qiu T.H. , Liu E.T. , Hunter K.W. ( 2002 ) A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency...
  10. Review: Contrasting genetic architectures in different mouse reference populations used for studying complex traits
    • David A. Buchner and
    • Joseph H. Nadeau
    Genome Res. June 2015 25: 775-791; Published in Advance May 7, 2015, doi:10.1101/gr.187450.114
    ..., Cleveland, Ohio 44106, USA; 2 Pacific Northwest Diabetes Research Institute, Seattle, Washington 98122, USA Corresponding authors: david.buchner@case.edu , jnadeau@pnri.org Abstract Quantitative trait loci (QTLs) are being used to study genetic networks, protein...
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