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  1. ...et al., 2008, 2010), the regulatory basis of the IFN 89 system, and more generally antiviral transcriptional responses, remains poorly understood. 90 To tackle this knowledge gap, we investigated the genomic regulatory mechanisms driving 91 core ISG expression responses in the head kidney of Atlantic...
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  2. ...of host s (Sotero-Caio et al. 2017). In humans, transposon-derived sequences are estimated to account for >60% of the genomic sequence (de Koning et al. 2011). Occasionally, transposon-encoded proteins have been “domesticated” as novel host proteins (Volff 2006).Transposons are typically classified...
  3. ...and Continuing Education, Hong Kong Baptist University, Shenzhen 518057, China ↵3 These authors contributed equally to this work. Corresponding author: zyzhao@hkbu.edu.hkAbstractUnderstanding how genomic divergence drives biodiversity remains a central question in evolutionary biology. The nematodes...
  4. ...networks remains to be seen.Previous work cloning and sequencing DNA from RELA ChIP led to the conclusion that ∼11% of NF-kB-bound regions contain an Alu-derived NF-kB motif (Antonaki et al. 2011). However, the extent to which specific subfamilies of repetitive elements contribute to NF-kB binding in human...
  5. ...introgressed genomic regions, mostly stochastically distributed across individuals (Supplemental Figs. S2, S3).Unlike neutral ancient introgression, if introgression conveys a selective advantage, population genetic theory predicts that introgressed genomic regions should be present at high frequency within...
  6. ...the chromosome's genomic sequence separated by intergenic stretches of DNA which are devoid of genes, in a strand-specific manner. However, in practice, the genomic organization is more complex, and genes can in reality occupy the same genomic space as each other and are considered as overlapping genes...
  7. ...conditions compared to kit v1, while the method of cDNA generation remains unchanged. Each of the three cDNA libraries was sequenced on one SMRT cell of the same sequencing run, and the sequencing reads were analyzed and compared using the same computational approach (see Methods). Comparably high numbers...
  8. ...source of ancient DNA. Genome Res 30: 427–436. doi:10.1101/gr.260141.119 ↵Skoglund P, Storå J, Götherström A, Jakobsson M. 2013. Accurate sex identification of ancient human remains using DNA shotgun sequencing. J Archaeol Sci 40: 4477–4482. doi:10.1016/j.jas.2013.07.004 ↵Skoglund P, Northoff BH, Shunkov...
  9. ...is particularly well characterized compared with other domestic mammals, with almost 3000 high-coverage s publicly available. Importantly, as the number of sequenced s increases, new avenues for analysis are becoming available. Herein, we discuss recent discoveries in canine genomics regarding behavior...
  10. ...: In this window In a new window Figure 5. Genomic identification of the zebra shark Chromosome X. (A) Male–female ratio of short-read sequencing depth in the shark chromosomes. (B) Male-female copy-number difference of zebra shark Chromosome X. Amplification levels of the genes on the PAR and the remainders...
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