Searching journal content for articles similar to Blanchette et al. 14 (12): 2412.

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  1. ...understood. Here, we use comparative genomics, expression across multiple ontogenetic stages and tissues, as well as polymorphism data to investigate MHC evolution in newts. Contrary to earlier suggestions of a massively expanded MHC in salamanders, we find that the core MHC region remains relatively compact...
  2. ...open chromatin in the face of warmer mammalian body temperatures, in genomic regions not already stabilized by compact chromatin structure (Saccone et al. 2002). In turn, avian microchromosomes were proposed to be counterparts of these mammalian GC-rich chromosomal segments found within chromosomes...
  3. ....J. , Eichler, E.E. ( 2001 ) Segmental duplications: Organization and impact within the current human project assembly . Genome Res. 11 : 1005 – 1017 . ↵ Blanchette, M. , Green, E.D. , Miller, W. , Haussler, D. ( 2004 ) Reconstructing large regions of an ancestral mammalian in silico . Genome Res. 14 : 2412...
  4. ...that the genomic regions are trans-acting factors. Identifying the mechanisms underlying trans-acting factors is however very difficult to approach in vitro as well as in silico, and our approach to detect the role of trans-acting factors over macroevolutionary time is novel. We opted for an in silico approach...
  5. ..., these errors are difficult to abolish by using longer genomic sequences or by analyzing more taxa. This study describes a new approach for improving ancestral genome reconstruction, the ancestral coevolver (ACE), which utilizes coevolutionary information to improve the accuracy of such reconstructions over...
  6. ...or millions of years and often involve large genomic regions that may contain important genes for intraspecific divergence and speciation (Wellenreuther and Bernatchez 2018).Despite the important role of inversions in evolution, they are difficult to detect and analyze in mammalian s owing to their balanced...
  7. ...of the genomic or epigenomic features. Herein we reconstructed the ancestral chromosome organization for several mammalian ancestral clades to investigate the functional role of EBRs in the context of changes that occurred for 60 million years (My) in the lineage leading to cattle.We used ruminants as a model...
  8. ...In silico phylogenomics using complete genomes: a case study on the evolution of hominoids Igor Rodrigues Costa 1 , 3 , Francisco Prosdocimi 1 , 3 and W. Bryan Jennings 2 1Laboratório de Genômica e Biodiversidade, Instituto de Bioquímica...
  9. ...Genome-wide nucleotide-level mammalian ancestor reconstruction Benedict Paten 1 , 4 , Javier Herrero 2 , Stephen Fitzgerald 2 , Kathryn Beal 2 , Paul Flicek 2 , Ian Holmes 3 , and Ewan Birney 2 , 4 1...
  10. ..., however, that these putative translocations were not experimentally validated and may simply reflect errors in the assemblies.We observed that genomic regions that were syntenic in the ancestral chromosome sometimes maintained their interaction even after loss of synteny occurred in gibbon due...
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