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  1. ..., Kuster B, et al. 2016. Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC). BMC Genomics 17: 133. doi:10.1186/s12864-016-2456-1 ↵Ochman H, Lawrence JG, Groisman EA. 2000. Lateral gene transfer and the nature...
  2. ...). However, because MGEs are vehicles for the exchange of beneficial accessory genes, defense systems could consequently impede rapid adaptation in microbial populations. Here, we study how defense systems impact horizontal gene transfer (HGT) in the short term and long term. By combining comparative...
  3. ...studies have sought to catalog driver events occurring in hundreds of cancer genes across different tumor types (Martincorena and Campbell 2015; Chung et al. 2016; Tokheim and Karchin 2019; Dietlein et al. 2020; Kumar et al. 2020; The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium 2020...
  4. ..., engagement in more frequent interspecific interactions, induces higher HTT rates, as found in bacteria exchanging genes (Popa and Dagan 2011; Dmitrijeva et al. 2024). Regarding the second factor, compatibility between TEs and recipient hosts may indeed play a role in conditioning horizontal transfers...
  5. ...to encode (for details, see Methods) 4127 protein-coding genes (Fig. 1A).View larger version: In this window In a new window Figure 1. Genome assembly and annotation of Bacteriovorax sp. ICPB 3264 [H-I A3.12]. (A) Circos (Krzywinski et al. 2009) plot of the Bacteriovorax sp. ICPB 3264 [H-I A3.12] chromosome...
  6. ...labels are transferred from well-annotated scRNA-seq data to less-annotated omics data, such as scATAC-seq. This approach leverages the gene expression profiles available in scRNA-seq to help annotate common cell types and even novel cell types for other omics data. However, the heterogeneous features...
  7. ...: 3389–3402. doi:10.1093/nar/25.17.3389 ↵Belknap KC, Park CJ, Barth BM, Andam CP. 2020. Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria. Sci Rep 10: 2003. doi:10.1038/s41598-020-58904-9 ↵Blin K, Shaw S, Augustijn HE, Reitz ZL, Biermann F, Alanjary M, Fetter A...
  8. ....07.029 ↵Chen YZ, Bennett CL, Huynh HM, Blair IP, Puls I, Irobi J, Dierick I, Abel A, Kennerson ML, Rabin BA, et al. 2004. DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). Am J Hum Genet 74: 1128–1135. doi:10.1086/421054 ↵Chen L, Chen JY, Zhang X, Gu Y, Xiao R, Shao C...
  9. ...-base resolution methylation levels for individual CpG sites across the . These resources also annotate hypomethylated regions commonly linked to gene promoters, as well as allele-specific methylation patterns relevant to genomic imprinting. Notable examples include MethBase (Song et al. 2013), MethBank (Zhang et...
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  10. ...derivative of the N2 strain. We use improved long-read sequencing and manual assembly of 43 recalcitrant genomic regions to overcome deficiencies of prior N2 and VC2010 assemblies and to assemble tandem repeat loci, including a 772 kb sequence for the 45S rRNA genes. Although many differences from earlier...
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