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Method: Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing
- Jamie K. Teer,
- Lori L. Bonnycastle,
- Peter S. Chines,
- Nancy F. Hansen,
- Natsuyo Aoyama,
- Amy J. Swift,
- Hatice Ozel Abaan,
- Thomas J. Albert,
- NISC Comparative Sequencing Program,
- Elliott H. Margulies,
- Eric D. Green,
- Francis S. Collins,
- James C. Mullikin,
- and Leslie G. Biesecker
Genome Res. October 2010 20: 1420-1431; Published in Advance September 1, 2010, doi:10.1101/gr.106716.110
...and technical hurdles of data storage and analysis remain high for most large projects. As a result, methods are needed for efficient comprehensive sequencing of targeted genomic regions. A number of genomic enrichment (or targeted capture) methods have been developed and used with varying levels of success...
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Commentary: Hypothesis-generating research and predictive medicine
- Leslie G. Biesecker
Genome Res. July 2013 23: 1051-1053; doi:10.1101/gr.157826.113
..., Cruz P, Hansen NF, et al. 2009. The ClinSeq Project: Piloting large-scale sequencing for research in genomic medicine. Genome Res 19: 1665–1674. Hennekam RC, Biesecker LG. 2012. Next-generation sequencing demands next-generation phenotyping. Hum Mutat 33: 884–886. International Human Genome Sequencing...

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