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Method: Accurate and efficient detection of gene fusions from RNA sequencing data
- Sebastian Uhrig,
- Julia Ellermann,
- Tatjana Walther,
- Pauline Burkhardt,
- Martina Fröhlich,
- Barbara Hutter,
- Umut H. Toprak,
- Olaf Neumann,
- Albrecht Stenzinger,
- Claudia Scholl,
- Stefan Fröhling,
- and Benedikt Brors
Genome Res. March 2021 31: 448-460; Published in Advance January 13, 2021, doi:10.1101/gr.257246.119
...be improved by supplying a list of structural variants obtained from WGS, which are incorporated into the filtering of equivocal predictions.Identification of oncogenic gene fusions in pancreatic cancerThe discovery of recurrent fusions involving NRG1 in KRAS wild-type pancreatic tumors (Heining et al. 2018...
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Research: New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation
- Le Li,
- Yuwei Gao,
- Qiong Wu,
- Alfred S.L. Cheng,
- and Kevin Y. Yip
Genome Res. April 2019 29: 543-553; Published in Advance February 19, 2019, doi:10.1101/gr.240036.118
...based on its promoter, body, and immediate downstream regions. It would be interesting to extend the study to include enhancer and other distal regulatory elements. Recently, a number of methods have been proposed for identifying target genes of enhancers in a cell-type–specific manner (Corradin et al...

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