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Research: Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants
- Lawrence H. Uricchio,
- Noah A. Zaitlen,
- Chun Jimmie Ye,
- John S. Witte,
- and Ryan D. Hernandez
Genome Res. July 2016 26: 863-873; Published in Advance May 18, 2016, doi:10.1101/gr.202440.115
...large samples. Weused recently inferred selectionmodels (Boyko et al. 2008; Torgerson et al. 2009), both of which are G-distributions of selection coefficients. For simulated coding regions, only nonsynonymous sites are under selection. For the simulations that we used to calculate genetic architecture...
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Perspective: Genetic architecture of quantitative traits in mice, flies, and humans
- Jonathan Flint and
- Trudy F.C. Mackay
Genome Res. May 2009 19: 723-733; doi:10.1101/gr.086660.108
...estimates of the locus-specific effect sizes that contribute to variation in complex phenotypes. Genome-wide association analyses of human case-control samples reveal that the genetic architecture of quantitative traits and disease consists of alleles of small effect size. With the exception of the HLA...

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