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  1. ...in a murine MPN model. This study was replicated in MPN patients by profiling -wide gene expression and DNA methylation using patient blood samples collected longitudinally, before and following HC exposure. The effects of HC on the transcriptome were not only associated with cell cycle interruption but also...
  2. ...,000 and mortality of 140,000, epithelial ovarian cancer is the leading cause of death among women with gynecological malignancies and a disease in urgent need for improved treatment (Ferlay et al. 2010). Large-scale genomic analysis of ovarian cancer patients has uncovered only a few recurrentlymutated genes...
  3. ...and acquired drug resistance are key steps in cancer progression that ultimately lead to treatment failure and patient mortality. To identify novel modalities to prevent cancer progression and improve patient survival, it is important to understand the underlying mechanisms that drive these processes. To date...
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