Searching journal content for articles similar to Beaulaurier et al. 35 (4): 929.

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  1. Review: Understanding isoform expression by pairing long-read sequencing with single-cell and spatial transcriptomics
    • Natan Belchikov,
    • Justine Hsu,
    • Xiang Jennie Li,
    • Julien Jarroux,
    • Wen Hu,
    • Anoushka Joglekar,
    • and Hagen U. Tilgner
    Genome Res. November 2024 34: 1735-1746; doi:10.1101/gr.279640.124
    ...in the donor's germline in a haplotype-resolved manner in order to investigate the complex genetic recombination patterns that are responsible for antibody production, demonstrating a powerful use case for combining the two modalities (Beaulaurier et al. 2024). A subject where virology intersects...
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  2. Method: Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy-chain locus
    • Mari B. Gornitzka,
    • Egil Røsjø,
    • Uddalok Jana,
    • Easton E. Ford,
    • Alan Tourancheau,
    • William D. Lees,
    • Zachary Vanwinkle,
    • Melissa L. Smith,
    • Corey T. Watson,
    • and Andreas Lossius
    Genome Res. October 2025 35: 2240-2251; Published in Advance August 21, 2025, doi:10.1101/gr.280400.125
    ...the generation of high-quality, contiguous haplotype-resolved assemblies. The pipeline utilizes a custom IGH reference that incorporates several common SVs to enable reference-based phasing of reads. Next, the phased reads are separately assembled de novo. We assessed the accuracy of the initial haplotype-resolved...
  3. Editorial: Long reads decipher genomes and transcriptomes and offer novel insights into biology and diseases
    • Ana Conesa,
    • Alexander Hoischen,
    • and Fritz J. Sedlazeck
    Genome Res. April 2025 35: xi-xiv; doi:10.1101/gr.280665.125
    ..., Ly L, Duty JA, Tyer C, Stevens C, Hung C-T, Sookdeo A, Drong AW, Kowdle S, Guzman-Solis A, et al. 2025. De novo antibody identification in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies. Genome Res (this issue) 35: 929–941. doi:10...
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