Searching journal content for articles similar to Balmant et al. 30 (8): 1131.

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  1. ...Systems Biology of Signal Transduction, German Cancer 15 Research Center (DKFZ), 69120 Heidelberg, Germany 16 8 These authors contributed equally. Either author can be listed first. 17 * Correspondence: falk.butter@fli.de (FB) 18 19 Abstract 20 A tightly regulated DNA damage response is critical...
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  2. ...of the paerucumarin biosynthesis gene cluster showed the strongest and most consistent effect (Supplemental Fig. S4). Closer examination of the presence of these genes in our data set revealed that these orthologs are exclusively present in some strains of the genus Serratia. Because the paerucumarin gene cluster has...
  3. .... S8D). In addition, motif enrichment analysis of up- and down-regulated 235 DACs identified by the pseudo-bulk method in dopaminergic neurons revealed an enrichment 236 for motif families such as ZF, HTH, and FOX, including CTCF, RFX, and FOXA1 (Supplemental 237 Fig. S8E,F). Foxa1 is a member...
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  4. ...in females and 98 metabolites in males were not genetically variable, and 43 of these metabolites were common in both sexes. These metabolites are likely tightly regulated at steady state. In females, they include common precursors for fatty acid biosynthesis (malonate and methylmalonate), building blocks...
  5. ...Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cisregulatory modules acting during vertebrate organogenesis Daniela M. Riley,1,7 Randa Elsayed,1,7 Mark D. Walsh,2,7 Simaran Johal,2 Ying Lin,3,4 Harry Walton,1 Till Bretschneider,5 Sascha Ott,1...
  6. ...Pan analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility Dongying Xie1,2,3, Pohao Ye1,3, Yiming Ma1 and Zhongying Zhao1 1Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China; 2Institute for Research...
  7. ...function and prognostic value. Notably, LTR7-PLAAT4, present in 29% of tumors, encodes a protein variant transcriptionally regulated by FOXM1 binding to the LTR7 promoter. LTR7-PLAAT4 isoform 2 is associated with increased cholesterol ester accumulation and lipid droplet formation mediated through BSCL2...
  8. ...–phenotype relationship will help guide the development of new drought-tolerant varieties. Systems genetics is a recent approach providing improved insight into this relationship by deciphering the biological networks and molecular pathways underlying complex traits and by investigating how these traits are regulated...
  9. ..., Spain; 3Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, 50018, Zaragoza, Spain Corresponding author: jaime.iranzo@cab.inta-csic.esAbstractProkaryotes have evolved a wide repertoire of defense systems to prevent invasion by mobile genetic elements (MGEs...
  10. ..., unlike in tRNAs, m3C sites in poly(A) RNAs are not specifically associated with loop structures.METTL2A downregulates m3C RNAsTo investigate the role of METTL2A in pancreatic cancer cells, we analyzed METTL2A-regulated genes in AsPC-1 cells. Direct RNA sequencing revealed that METTL2A knockdown led...
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