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  1. ..., the Great Salt Lake, and the Dead Sea. About four years ago, we sequenced the of the first halophilic archaeon, that of Halobacterium sp . NRC-1, because we were fascinated about how protein structures as well as metabolic strategies and physiologic responses might be altered to meet this extreme high...
  2. ...candidate for such global analysis is Halobacterium NRC-1, an archaeon that thrives in a >4.0 M salinity environment. This halophile is easily cultured and manipulated in the laboratory and has a range of systems-analysis tools available for its inquiry ( Weston et al. 2003 ). In this report, we describe...
  3. ...: a photoheterotrophic halophile (Halobacterium salinarumNRC-1), a hydrogenotrophic methanogen (Methanococcus maripaludis S2), an acidophilic and aerobic thermophile (Sulfolobus solfataricus P2), and an anaerobic hyperthermophile (Pyrococcus furiosus DSM 3638). We demonstrate how the evolution of transcriptional...
  4. ...across these distinct but interconnected processes remain to be characterized to build a physiological model of systems behavior. We chose the haloarchaeon Halobacterium salinarum NRC-1 as a model organism to investigate the systems-level oxygen response. This organism, found in the Great Salt Lake...
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