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Resource: Quadrupia provides a comprehensive catalog of G-quadruplexes across genomes from the tree of life
- Nikol Chantzi,
- Akshatha Nayak,
- Fotis A. Baltoumas,
- Eleni Aplakidou,
- Shiau Wei Liew,
- Jesslyn Elvaretta Galuh,
- Michail Patsakis,
- Austin Montgomery,
- Camille Moeckel,
- Ioannis Mouratidis,
- Saiful Arefeen Sazed,
- Wilfried Guiblet,
- Panagiotis Karmiris-Obratański,
- Guliang Wang,
- Apostolos Zaravinos,
- Karen M. Vasquez,
- Chun Kit Kwok,
- Georgios A. Pavlopoulos,
- and Ilias Georgakopoulos-Soares
Genome Res. November 2025 35: 2578-2600; Published in Advance August 26, 2025, doi:10.1101/gr.279790.124
...category, and the user has the option to explore the full set of G4s for each with additional annotations.Quadrupia offers experimental validation for the G4 sequences of selected s in three forms: (1) genomic coordinate matches to experimentally validated G4 sequences, as described in the study by Marsico...
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METHODS: A Complexity Reduction Algorithm for Analysis and Annotation of Large Genomic Sequences
- Trees-Juen Chuang,
- Wen-Chang Lin,
- Hurng-Chun Lee,
- Chi-Wei Wang,
- Keh-Lin Hsiao,
- Zi-Hao Wang,
- Danny Shieh,
- Simon C. Lin,
- and Lan-Yang Ch'ang
Genome Res. February 1, 2003 13: 313-322; doi:10.1101/gr.313703
.... , Fischer S. , Schug J. , Crabtree J. , Gibson M. , Overton G.C. ( 1998 ) GAIA: Framework annotation of genomic sequence. Genome Res. 8 : 234 – 250 . ↵ Birney E. , Durbin R. ( 2000 ) Using GeneWise in the Drosophila annotation experiment. Genome Res. 10 : 547 – 548 . ↵ Burge C.B. , Karlin S. ( 1997...
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RESEARCH: Analysis of EST-Driven Gene Annotation in Human Genomic Sequence
- L. Charles Bailey, Jr.,
- David B. Searls,
- and G. Christian Overton
Genome Res. April 1, 1998 8: 362-376; doi:10.1101/gr.8.4.362
...Analysis of EST-Driven Gene Annotation in Human Genomic Sequence L. Charles Bailey, Jr. 1 , 3 , David B. Searls 1 , 2 , and G. Christian Overton 1 1Computational Biology and Informatics Laboratory, Department of Genetics, University...

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