Searching journal content for articles similar to Arts et al. 13 (10): 2325.

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  1. Method: Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth
    • Wonjoo Kim,
    • Sangeun Lee,
    • Han Sang Kim,
    • Minjung Song,
    • Yong Hoon Cha,
    • Young-Hoon Kim,
    • Jeonghong Shin,
    • Eun-Seo Lee,
    • Yeonsoo Joo,
    • Jae J. Song,
    • Eun Ju Choi,
    • Jae W. Choi,
    • Jinu Lee,
    • Moonkyung Kang,
    • Jong In Yook,
    • Min Goo Lee,
    • Yeon-Soo Kim,
    • Soonmyung Paik,
    • and Hyongbum (Henry) Kim
    Genome Res. March 2018 28: 374-382; Published in Advance January 11, 2018, doi:10.1101/gr.223891.117
    ...the identification of tumor-essential genes and tumor-promoting mutations in vivo. Cell Rep 10: 1422–1432. ↵Baumer S, Baumer N, Appel N, Terheyden L, Fremerey J, Schelhaas S, Wardelmann E, Buchholz F, Berdel WE, Muller-Tidow C. 2015. Antibody-mediated delivery of anti–KRAS-siRNA in vivo overcomes therapy resistance...
  2. Methods: Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis
    • Josephine N. Harada,
    • Kristen E. Bower,
    • Anthony P. Orth,
    • Scott Callaway,
    • Christian G. Nelson,
    • Casey Laris,
    • John B. Hogenesch,
    • Peter K. Vogt,
    • and Sumit K. Chanda
    Genome Res. August 2005 15: 1136-1144; Published in Advance July 15, 2005, doi:10.1101/gr.3889305
    ...of genome-scale siRNA and cDNA arrayed libraries enable the comprehensive global analysis of gene function. However, the current repertoire of high-throughput detection methodologies has limited the scope of cellular phenotypes that can be studied. In this report, we describe the systematic identification...
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  3. LETTER: Early Genetic Mechanisms Underlying the Inhibitory Effects of Endostatin and Fumagillin on Human Endothelial Cells
    • Chiara M. Mazzanti,
    • Anita Tandle,
    • Dominique Lorang,
    • Nick Costouros,
    • David Roberts,
    • Generoso Bevilacqua,
    • and Steven K. Libutti
    Genome Res. August 2004 14: 1585-1593; doi:10.1101/gr.2552804
    ...separately transfected HUVECs with a vector containing siRNA targeting the DOC1 gene (psiRNA-Neo-Doc1) and a vector containing a sequence (psiRNA-Neo-Control), which, after BLAST search, resulted in complementary binding only to the intronic sequence of the human Tyrosine Hydroxylase gene. Figure 6...
  4. PERSPECTIVE: Impact of genomics on research in the rat
    • Jozef Lazar,
    • Carol Moreno,
    • Howard J. Jacob,
    • and Anne E. Kwitek
    Genome Res. December 2005 15: 1717-1728; doi:10.1101/gr.3744005
    ...or implicated to be causal, there is a need to prove the causality, a phase of gene discovery termed target validation. The gold standard for proving that a gene is causal is to knock in the particular allele or mutation responsible for the trait, or replace the defect with a “normal” allele to demonstrate...
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