Searching journal content for articles similar to Abewe et al. 35 (3): 393.

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  1. ...integrative analysis of human and mouse regulatory landscapes across progenitor and mature blood cell types. The features included chromatin accessibility, which is a hallmark of almost all regulatory elements, occupancy by the structural protein CTCF, and histone modifications associated with gene activation...
  2. ...of ESR1 chromatin occupancy, the transcriptional program converges in the estrogen response owing to a redundancy of distal regulatory element binding by ESR1.ERE strength weakly associates with the level of inter-tumor conservation of ESR1 sitesFrom cell lines, ESR1 DNA binding is known to be enriched...
  3. ...impact of genetic variants within regulatory regions. In summary, TOP offers a cost-effective strategy for profiling the quantitative occupancy of hundreds of TF motifs using only a single chromatin accessibility experiment, markedly enhancing our ability to explore quantitative changes in TF occupancy...
  4. .... Alternatively, these regions may actually be depleted for regulatory elements. This could be due to constraints imposed by the chromatin structure of the nuclear architecture, making it more difficult for the DNA of these regions to come in physical proximity to the TSS. After the first 50 kb upstream...
  5. ...-acting regulatory elements that control transcription from a distance through the formation of contacts between the enhancer-bound transcription factors and promoter-bound Pol II and the looping out of intervening chromatin (Kagey et al. 2010b). BRD4 and components of the P-TEFb complex have been shown...
  6. .... 2011). We find that in cells with intact GATA3 (siControl), EP300 is redistributed upon estrogen stimulation from regions not bound by ESR1 to regions co-occupied by ESR1–EP300, showing that estrogen induces recruitment of EP300 only to a subset of cis-regulatory elements (Supplemental Fig. 3A...
  7. ...to recruitment of large enzymatic complexes that lead to activation or repression by altering histone modifications or chromatin structure (Maston et al. 2006; Jiang and Pugh 2009). Some cis-regulatory modules (CRMs), containing clusters of binding sites for transcription factors (Maniatis et al. 1987...
  8. ...IP-chip”) have been instrumental in defining regulatory sequences in yeast and mammals ( Horak et al. 2002 ; Lee et al. 2002 ; Blais et al. 2005 ). A related technique called serial analysis of chromatin occupancy has recently been reported for the definition of the cyclic AMP response element binding protein...
  9. ...%–8% of the and impacting many cellular processes (Sanz et al. 2016; Wahba et al. 2016). For instance, R-loops (1) drive embryonic stem cell differentiation via modulating the chromosomal binding of chromatin-regulatory complexes (Chen et al. 2015), (2) ensure the optimal binding of transcriptional activators...
  10. ...proceeds via activation of the ER-regulated gene expression program that mediates re-entry into cell cycle. The functional effect of RNAimediated removal of candidate regulators on estrogen-induced proliferation can be used to determine whether cofactors are required for ER-driven transcription (Prall et...
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