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  1. Review: A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest
    • Andrew D. Bates,
    • Dawid Grzela,
    • Maciej Studzian,
    • Louise Brennan,
    • Moli Williams,
    • Conor Fawcett,
    • Beth Hammond,
    • Manreen Grewal,
    • Marcin Ratajewski,
    • Lukasz Pulaski,
    • and Urszula L. McClurg
    Genome Res. March 2026 36: 433-459; Published in Advance February 17, 2026, doi:10.1101/gr.281154.125
    ...annotations. Moreover, differential splicing, overlapping transcripts, or polymorphisms could further complicate interpretation, as probes were not always isoform specific.Expression profiles generated by microarrays were thus limited to what the array was “designed to see,” making it a hypothesis-limited...
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  2. ERRATUM: Errata for vol. 9, p. 673 Genome Res. November 1, 1999 9: 1156
    ...1549-5469 1088-9051 genome;9/11/1156 Errata for vol. 9, p. 673 Errata for vol. 9, p. 673 Genome Research 9:  673–674 (1999) Hypothesis-Limited Research Laurie Goodman The above-mentioned paper incorrectly cited Spellman et al. (1998) from Mol. Cell. Biol. The paper appeared in Mol. Biol. Cell...
  3. INSIGHT/OUTLOOK: Methodological Function of Hypotheses in Science: Old Ideas in New Cloth
    • Krzysztof Łastowski and
    • Wojciech Makałowski
    Genome Res. March 1, 2000 10: 273-274; doi:10.1101/gr.10.3.273
    ...National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 USA The August 1999 issue of Genome Research presented a very interesting editorial, “Hypothesis-Limited Research,” on the status and discovery function of scientific...
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