Shuffling of Genes Within Low-Copy Repeats on 22q11 (LCR22) by Alu-Mediated Recombination Events During Evolution
C2 1 gttggccagg ctggtctcca actcctgacatcgtgatcca cccgcctccg
C2a1 1 aaggtccccaaggcagtggcgaggaggagatgaggaggtcaaggaggaga
C2a2 1 --ggtccccaaggcagtggcgaggaggagatgaggaggtcaaggaggaga
C2a3 1 aaggtccccaaggcagtggcgaggaggagatgaggaggtcaaggaggaga
AluY 1 ---------- ---------- ---------- ---------- ----------
C2 51 cctcccaaag tgccaccgcg cccggccttt tttttttaag acagagtctc
C2a1 51 c--agaggatggacccgaaggccgaagaaaatgcctcaagggagtttcaa
C2a2 49 cagagaggatggacccgaaggccgaagaaaatgcctcaagggagtttcaa
C2a3 51 c--agaggatggacccgaaggccgaagaaaatgcctcaagggagtttcaa
AluY 1 ---------- ---------- ---------- ---------- ----------
C2 101 GGCCCGGCGCGGTGGCTCACGCCTTTAATCCCGGCACTTTGGGAGGCCGA
C2a1 99 CACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGG---
C2a2 99 CACCGGGCGCGGTGGCTCACGGCTGTAATCCCAGCACTTTGGGAGGCCGA
C2a3 99 CACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGA
AluY 1 GGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGA
C2 151 GGC------- ---------- -----GGGCT GATCACGAGGTCAGGAGATC
C2a1 146 ---------- ---------- ---------GGATCACGACGTCAGGAGATG
C2a2 149 GGCCTGTAAT CCCAGCACTTTGGGAGGGCGGATCACGACGTCAGGAGATC
C2a3 149 GGCCTGTAAT GCCAGCACTTTGGGAGGGCGGATCATGACGTCAGGAGATG
AluY 51 GGC------- ---------- -----GGGCGGATCACGAGGTCAGGAGATC
C2 179 GAGACCATCCTGGCTAACACGGTGAAACCC TGTCTCTACTAAAAATGCAA
C2a1 167 GAGATCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAA
C2a2 199 GAGACCATCCTGGCTAACAC AGTGAAACCCCGTCTCTACTAAAAATACAA
C2a3 199 GAGATCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAA
AluY 79 GAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAA
C2 229 AAAATTAGCCGGGTGTGATGGCGGGCGCCTGTAGTCCGAG ---CTACTCC
C2a1 217 AACATTAGCCGGGTGTGGTGGCGGGCGCCTGCAGTCCCA- --ACTACTCC
C2a2 249 AAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCA- --ACT---CC
C2a3 249 AAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCAA CTACT---CC
AluY 129 AAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGG--
C2 276 AGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGTAGGCGGAGCTTGCGGT
C2a1 264 AGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGTAGGCGGAGCTTGCGGT
C2a2 293 AGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGTAGGCGGAGCTTGCGGT
C2a3 296 AGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGTAGGCGGAGCTTGCGGT
AluY 177 -GAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGT
C2 326 GAGCC--GAGATCAGGCCACTGGAATCCAGCCTGGGCGACAGAGGGAGAC
C2a1 314 GAGCT--GAGATCAGGCCACTGGAATCCAGCCTGGGCGAT AGAGGGAGAC
C2a2 343 GAGCC--GAGATCAGGCCACTGGAATCCAG GCTGGGCGACAGAGGGAGAC
C2a3 346 GAGCCCAGAGATCAGGCCACTGGAATCCAGCCTGGGCGACAGAGGGAGAC
AluY 226 GAGCC--GAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGAC
C2 374 TCCGTCTCAaaaaaaaaaaaaaaaaaaaa- --------agagtctggctc
C2a1 362 TCCATCTCAaaaaaaaaaaaaaaaaaagag aga------gagtctggctc
C2a2 391 TCCATCTCAaaaaaaaaaaaaaaaaaaaaa --a------gagtctggctc
C2a3 396 TCCATCTCAaaaaaaaaaaaaaaaaaaaaa --aaagagagagtctgactc
AluY 274 TCCGTCTCA- ---------- ---------- ---------- ----------
C2 415 tgttgcccag ggctggagtgcagtggcgcgatctcggcgcatcacaatcc
C2a1 406 tgttgccca- ggctggagtgcagtggcgcgatctcggcgcatcacaatcc
C2a2 433 tgttgccca- ggctggagtgcagtggcgtgatctcggcacatcacaatcc
C2a3 444 tgttgccca- ggctggagtgcaatggtgcgatctcagctcactgcaatct
AluY 283 ---------- ---------- ---------- ---------- ----------
C2 465 cttcccc
C2a1 455 cttcccc
C2a2 482 cttcccc
C2a3 493 ccacctc
AluY 283 -------
