Shuffling of Genes Within Low-Copy Repeats on 22q11 (LCR22) by Alu-Mediated Recombination Events During Evolution
B2 1 ttcctgatagagacaccgattcctggaggtccaaagagcctcaggagctg
B2a1 1 ttcctgatagagacaccgattcctggaggtccaaagagcctcaggagctg
B2a2 1 ttcctggtagagacaccgattcctggaggtccaaagagcctcaggagctg
AluSq 1 ---------- ---------- ---------- ---------- ----------
B2 51 ggccagcaatatgcagcatctattatggacacagaacattcccatcacat
B2a1 51 ggccagcaatatgcagcatctattatggacacagaacattcccatcacat
B2a2 51 ggccagcaatatgcagcatctattatggacacagaacattcccatcacat
AluSq 1 ---------- ---------- ---------- ---------- ----------
B2 101 GGCCGGGTGCAGTGGCTCAC ACCTATAATCCCAGCACTTTGGGAGGCAGA
B2a1 101 GGCCGGGTGCAGTGGCTCACGCCTATAATCCCAGCACTTTGGAAGGCAGA
B2a2 101 GGCCGGGTGCAGTGGCTCACGCCTTTAATCCCAGCACTTTGGGAGGCAGA
AluSq 1 GGCCGGGCGC GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGA
B2 151 GGCAGGTGGATCACCTGAGGTGAAGAGTTT GAGAACAGCCTGGCCAACAT
B2a1 151 GGCAGGTGGATCACCTGAGGTGAAGAGTTCGAGACCAGTCTGGCCAACAT
B2a2 151 GGCAGGTGGATCACCTGAGGTGAAGAGTTCGAGACCAGTCTGGCCAACAT
AluSq 51 GGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAT
B2 201 GGTGAAACCCCCATCTCCACTAAAAATACAAAAAATTAGCCAGGCATGGT
B2a1 201 GGTGAAACCCCCATCTCCACTAAAAATACAAAAAATTAGCCAGGCATGGT
B2a2 201 GGTGAAACCCCCATCTCCACTAAAAATACAAAAAATTAGCCAGGCATGGT
AluSq 101 GGTGAAACCCCG-TCTCTACTAAAAATACAAAAA-TTAGCCGGGCGTGGT
B2 251 GGCAGGTGCCTGTAATCCCAGCTACTCAGGA-GCTGAGGCAGGAGAATTG
B2a1 251 GGCAGGTGCCTGTAATCCCAGCTACTCAGGA-GCTGAGGCAGGAGAATTG
B2a2 251 GGCAGGTGCCTGTAATCCCAGCTACTCAGGA-GCTGAGGCAGGAGAATTG
AluSq 149 GGCGGGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCG
B2 300 CTTGAACCCA GGAGGTGGAGGTTGCAGTGAGGCAAGATTGCACCACTGCA
B2a1 300 CTTGAACCCGGGAGGTGGAGGTTGCAGTGAGGCAAGATTGCACCACTGCA
B2a2 300 CTTGAACCCGGGAGGTGGAGGTTGCAGTGAGGCAAGATTGCACCACTGCA
AluSq 199 CTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCA
B2 350 CTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAaaaa aaatgcaaaa
B2a1 350 CTCCAGCCTGGGCCACAAGAGTGAAACTCCGTCACAcacacacacacaca
B2a2 350 CTCCAGCCTGGGCCACAAGAGTGAAACTCCGTCACAcacacacacacaca
AluSq 249 CTCCAGCCTGGGCAACAAGAGCGAAACTCCGTCTCA---- ----------
B2 400 aaacaaaaac ---------- -------aaaaggacatttccaccacaagt
B2a1 400 cacaca---- ---------- -agaaaaaaaaggtctcctgctgggacaca
B2a2 400 cacacacaaa aaaaaaaaaa aagaaaaaaaaggtctcctgctggaacaca
AluSq 285 ---------- ---------- ---------- ---------- ----------
B2 433 catggggcag gggcctggcc tggtcagtga ccccgtccta gcatgacagc
B2a1 435 gactagttagagaaaggaaaaataaacaaatgatagtatgtgtattaata
B2a2 450 gactagttagagaaaggaaaaataaacaaatgatagtatgtgtattaata
AluSq 285 ---------- ---------- ---------- ---------- ----------
B2 483 cccctgcacc aaggaagcta cccagtcccgtc
B2a1 485 aaagaactagcaacacccactgcttagttgtg
B2a2 500 aaagaactagcaacacccactgcttagttgtg
AluSq 285 ---------- ---------- ---------- --
