Shuffling of Genes Within Low-Copy Repeats on 22q11 (LCR22) by Alu-Mediated Recombination Events During Evolution

        A3       1  GGCTGGGCACGGTGGCTCACGCCTGTAATCCCTGCACTTTGGGAGACTGA 
      A3b1       1  ---------- ---------- ---------- ---------- ---------- 
      A3b2       1  ---------- ---------- ---------- ---------- ---------- 
      AluY       1  GGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGA 

        A3      51  GGTGGGCAGATCATGAGGTCAGGAGATTGA GACCATCCTG GCTAACACGG 
      A3b1       1  ---------- ---------- TTAATGCAAC CTGCTGAAAATAGGCATGGA 
      A3b2       1  ---------- ---------- TTAATGCAAC CTGCTGAAAATAGGCATGGA 
      AluY      51  GGCGGGCGGATCACGAGGTCAGGAGATCGA GACCATCCTG GCTAACACGG 

        A3     101  TGAAACCCTG TCTCTACTAAAAATACAAAAAGTTAGCCGG GCGTGGTGGC 
      A3b1      31  AAAACTAGAAAATCTAGAAAAATTAGAAAA TCACTGAAGAGGATTTTCTT 
      A3b2      31  AAAACTAGAAAATCTAGAAAAATTAGAAAA TCACTGAAGAGGATTTTCTT 
      AluY     101  TGAAACCCCG TCTCTACTAAAAATACAAAAAATTAGCCGG GCGTGGTGGC 

        A3     151  GGGCGCCTGT AGTCCCAGCCACTCGGGAGGCTGAGGAGGGAGAATCGTTT 
      A3b1      81  TAAAAAAATA CATACTTTAAACTCGGGAGGCTGAGGAGGGAGAATCGTTT 
      A3b2      81  TAAAAAAATA CATACTTTAAACTCGGGAGGCTGAGGAGGGAGAATCGTTT 
      AluY     151  GGGCGCCTGT AGTCCCAGCT ACTCGGGAGGCTGAGGCAGGAGAATGGCGT 

        A3     201  GAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTC 
      A3b1     131  GAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTC 
      A3b2     131  GAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTC 
      AluY     201  GAACCCGGGAGGCGGAGCTTGCAGTGAGCC GAGATCGCGCCACTGCACTC 

        A3     251  TAGCCTGGGCTACAGGGCAAGACTCCATTAAAaaaaaaaa aaaaaaaacc 
      A3b1     181  TAGCCTGGGCTACAGGGCAAGACTCCATTAAAaaaaaaaa ---aaaaacc 
      A3b2     181  TAGCCTGGGCTACAGGGCAAGACTCCATTAAAaaaaaaaa ---aaaaacc 
      AluY     251  CAGCCTGGGC GACAGAGCGAGACTCCGTCT CA-------- ---------- 

        A3     301  agcaaaaaccaaacaaaacataatgcatgttctctcttataaatgggagc 
      A3b1     228  agcaaaaaacaaacaaaacataatgcatgttctctcttataaatgggagc 
      A3b2     228  agcaaaaaccaaacaaaacataatgcatgttctctcttataaatgggagc 
      AluY     283  ---------- ---------- ---------- ---------- ---------- 

        A3     351  taaacatggggactcattgacttaaagatggcaacaactgggaactgc-- 
      A3b1     278  taaacatggggactcattgacttaaagatggcaacaactgggaactgctg 
      A3b2     278  taaacatggggactcattgacttaaagatggcaacaactgggaactgctg 
      AluY     283  ---------- ---------- ---------- ---------- ---------- 

        A3     399  ---------- -------- 
      A3b1     328  gatggggagggaggggag 
      A3b2     328  gatggggagggaggggag 
      AluY     283  ---------- -------- 

    

This Article

  1. doi: 10.1101/gr.1549503 Genome Res. December 2003 vol. 13 no. 12 2519-2532

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