Interactions between TFs. (A) Different modes of interaction between TFs are shown. Each bar indicates the canonical TF and one noncanonical TF whose motifs were identified in the same ChIP-seq data set, and the red, blue, and black segments of the bar indicate percentage of peaks in the ChIP-seq data set that contain only canonical motif sites, only noncanonical motif sites, or both. Cartoons depict examples of different models for TF-TF interactions. (B) Circos plot (Krzywinski et al. 2009) on the left depicts pairs of motifs (connected by an arch) with significant distance preferences between their sites. The thickness of a connection is proportional to the normalized frequency of the pair. A connection is depicted as blue, black, or red when the motif pair is discovered in different data sets, the same data set, or both, respectively. The heat map on the right shows the distributions of distances between motif pairs. Each row is a motif pair in a particular ChIP-seq data set, and each column represents an edge-to-edge distance (from 0 bp to 99 bp). (C) Similar to B except showing motif pairs discovered in repetitive regions.
