Figure 5.
Trisomy 16 detected in interphase cells by the chromosome 16 telomeric BAC. BAC 43D12 linked to D16Mit52 was used to define cells from the Ts16 mouse model of Down syndrome. Three sets of FITC signals are clearly seen on 90% of interphase cells in contrast to probes from other chromosomes that produce just two pairs of signals (data not shown).
