The Sox10Dom Mouse: Modeling the Genetic Variation of Waardenburg-Shah (WS4) Syndrome

Table 1.

Comparison of Sox10 Splice Sites in Mouse and Human

Exon number Exon size (bp) Splice site
3′ 5′
1 Mus  >46 CTTCATGGAAgtgagagacaccccctccc
Hum N.D. N.D.
2 Mus  225 ccccctccttccttccccagCCGTCTGCAG GTCGGAGGAGgtgagtgcgcactgcgcccc
Hum  221 agccctccgcagcggctcagGCTCAGTCGC GTCCGAGGAGgtgagtgcgcagcctgctcc
3 Mus  506 gcgccctccttcccgtccagGTGGGCGTTG AGCTCTGGAGgtgagcgctgccccggccca
Hum  512 cgcgccctccttccatccagGTGGGCGTTG AGCTCTGGAGgtgagcacccgaccgccccc
4 Mus  269 ctgatgtcctccactcccagGTTGCTGAAC CACCCCTCAGgtgagtgctgggttctgggt
Hum  269 cgcctcccaccacaccccagGCTGCTGAAC CACCCCTCAGgtgagtgctgatgacagagc
5 Mus 1720 ccccctctcctcctacccagGCCAGAGCCA
Hum 1890 tctgtctcccttctacccagGCCAGAGCCA
  • The position of the 3′ splice site for human exon 2 (bold) was approximated by sequence alignments of rat and mouse exon–intron junctions with the genomic human sequences of this region. The longest available human cDNA clones terminated 23 bp 3′ of this position. (N.D.) Not determined.

This Article

  1. Genome Res. 9: 215-225

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