
A C3H.Sox10Dom mouse poised above the structural model of the SOX10 HMG box displays a white forelock. Variation in hypopigmentation has been observed for both WS4 patients and Sox10Dom mice. Congenic lines of Sox10Dom mice were used to look at modified loci of hypopigmentation. Artwork by Darryl Leja. (For details, see Southard-Smith et al., p. 215.)