The Genexpress IMAGE Knowledge Base of the Human Brain Transcriptome: A Prototype Integrated Resource for Functional and Computational Genomics

Table 2.

Characterization of Seven Gene Transcripts Selected as Preferentially Expressed in Brain

GENX Sequence similarity GenBank, SWISS-PROT* accession no. Genexpress clone (1NIB) name IMAGE clone ID GenBank/ EMBL accession no. Insert size (kb) Transcript size (kb) Chromosomal localization Orphan neurologic pathologies
465 RELRattus norvegicus calcium- independent α-latrotoxin receptor U72487U78105 O09026 *O35818 * c-0obo3 34591 Z42577 F02089 1.4 7.5 4q12
769 ID clone 23682 mRNA sequence ID clone 24440 mRNA sequence ID mRNA for KIAA0513 protein U79288AF055005 AB011085 c-08e08 57147 Z42089 F01625 1.7 7.5 16q24.3
3809 ID protein Armadillo multigene family (Hatzfeld and Natchtsheim 1996) X81889Q99569 * c-01d10 31734 Z42486 Z38681 1.5 4.6 2q22.3–q24.2
3960 ID visinin-like protein1 (Polymeropoulos et al. 1995) U14747P42323 * c-11h05 49279 F06242 F02525 1.5 2 2
4044 REL mouse and cattle cyclin-dependent kinase regulatory subunit P35 S73375S82819 c-0ge07 26501 Z42350 Z38574 1.8 4.2 17p11.2–q12 DFNB3 DDPAC
4858 ID human DNA sequence Chr22 Z99716 Z82192 c-03a10 32335 Z41917 Z38211 1.8 6.0/2.6 22q13.1–q13.3
200991 ID clone 23876 neuronal olfactomedin-related ER localized protein mRNA U79299AF035301 Q99784 * c-0oa03 34458 F05835 F02082 1.4 2.6 9q34.1–34.3 ALS4
  • GENX number refers to the Genexpress Index 2 cluster of cDNA clones, sequences, and ESTS markers.

  • Classification of each GENX cluster is based on data base similarities. Sequences were classified as known (ID) if identical to a human sequence and related (REL) if having a partial similarity to a sequence in another species.

  • When a significant sequence similarity was found, the GenBank or SWISS-PROT (with an asterisk) accession no. is reported.

  • (DFNB3) Neurosensory recessive deafness 3; (DDPAC) frontotemporal dementia with parkinsonism with variable phenotypes; ALS4) familial ALS.

This Article

  1. Genome Res. 9: 195-209

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