Genetic Plasticity of V Genes Under Somatic Hypermutation: Statistical Analyses Using a New Resampling-Based Methodology

Table 1.

Quantiles of Individual Real VH Sequences Within Each of the Three Variant Sets Generated by Resampling

Gene Nucleotide permutations Codon permutations Translationally equivalent
μ F μ C μ C /μ F μ F μ C μ C /μ F μ F μ C μ C /μ F
HumanVH 1 genes
IGHV1–18 0.783 0.976 0.914 0.396 0.074 0.134 0.154 0.536 0.729
IGHV1–2 0.725 0.776 0.662 0.582 0.168 0.17 0.093 0.107 0.331
IGHV1–24 0.617 0.225 0.207 0.236 0.11 0.184 0.0745 0.6 0.797
IGHV1–3 0.861 0.92 0.783 0.639 0.078 0.077 0.287 0.478 0.598
IGHV1–45 0.896 0.84 0.66 0.735 0.241 0.177 0.351 0.118 0.175
IGHV1–46 0.805 0.969 0.898 0.134 0.359 0.566 0.191 0.709 0.824
IGHV1–58 0.815 0.779 0.637 0.474 0.477 0.485 0.221 0.552 0.65
IGHV1–69 0.878 0.885 0.731 0.49 0.561 0.563 0.19 0.787 0.863
IGHV1–8 0.837 0.47 0.313 0.257 0.07 0.142 0.154 0.137 0.292
IGHV1–f 0.931 0.8 0.547 0.66 0.187 0.163 0.344 0.529 0.61
Human VH 2 genes
IGHV2–26 0.549 0.177 0.193 0.445 0.04 0.082 0.034 0.783 0.943
IGHV2–5 0.463 0.484 0.508 0.548 0.317 0.311 0.014 0.742 0.94
IGHV2–70 0.426 0.571 0.599 0.365 0.243 0.343 0.007 0.907 0.991
HumanVH3 genes
IGHV3–11 0.74 0.95 0.872 0.564 0.762 0.717 0.055 0.922 0.977
IGHV3–13 0.829 0.866 0.725 0.906 0.477 0.284 0.42 0.776 0.79
IGHV3–15 0.592 0.554 0.498 0.415 0.192 0.238 0.24 0.61 0.708
IGHV3–16 0.159 0.216 0.397 0.472 0.286 0.307 0.019 0.579 0.826
IGHV3–19 0.227 0.221 0.364 0.507 0.294 0.308 0.061 0.564 0.76
IGHV3–20 0.178 0.363 0.555 0.516 0.07 0.081 0.018 0.6 0.895
IGHV3–21 0.481 0.995 0.987 0.504 0.787 0.752 0.03 0.991 0.999
IGHV3–23 0.815 0.953 0.858 0.721 0.322 0.256 0.126 0.941 0.971
IGHV3–30.3 0.766 0.849 0.687 0.678 0.438 0.371 0.088 0.956 0.987
IGHV3–30 0.679 0.752 0.634 0.608 0.576 0.515 0.097 0.938 0.975
IGHV3–33 0.594 0.862 0.789 0.606 0.542 0.488 0.026 0.916 0.984
IGHV3–35 0.254 0.211 0.342 0.367 0.279 0.345 0.037 0.571 0.799
IGHV3–38 0.523 0.819 0.785 0.37 0.224 0.294 0.039 0.856 0.954
IGHV3–43 0.388 0.731 0.753 0.467 0.367 0.393 0.058 0.867 0.961
IGHV3–47 0.614 0.981 0.952 0.434 0.715 0.727 0.131 0.986 0.994
IGHV3–48 0.76 0.995 0.966 0.663 0.924 0.864 0.136 0.995 0.997
IGHV3–49 0.627 0.888 0.815 0.678 0.096 0.09 0.204 0.767 0.854
IGHV3–53 0.495 0.983 0.97 0.341 0.527 0.605 0.022 0.878 0.975
IGHV3–64 0.77 0.955 0.872 0.734 0.447 0.356 0.177 0.955 0.971
IGHV3–66 0.629 0.978 0.944 0.395 0.479 0.533 0.059 0.899 0.967
IGHV3–7 0.741 0.759 0.603 0.737 0.516 0.411 0.071 0.89 0.962
IGHV3–72 0.197 0.966 0.977 0.269 0.686 0.77 0.038 0.893 0.979
IGHV3–73 0.504 0.967 0.943 0.656 0.53 0.456 0.022 0.863 0.969
IGHV3–74 0.555 0.957 0.92 0.657 0.635 0.552 0.063 0.971 0.992
IGHV3–9 0.306 0.813 0.848 0.639 0.258 0.226 0.036 0.966 0.994
IGHV3–d 0.574 0.742 0.692 0.383 0.226 0.291 0.124 0.82 0.909
HumanVH 4 genes
IGHV4–28 0.415 0.936 0.923 0.293 0.357 0.489 0.001 0.59 0.933
IGHV4–301 0.625 0.964 0.923 0.35 0.005 0.049 0.031 0.472 0.779
IGHV4–302 0.545 0.79 0.751 0.228 0.034 0.121 0.019 0.493 0.775
IGHV4–304 0.477 0.971 0.952 0.254 0.009 0.095 0.01 0.63 0.912
IGHV4–31 0.64 0.962 0.918 0.336 0.006 0.05 0.041 0.466 0.76
IGHV4–34 0.359 0.837 0.851 0.146 0.224 0.427 0.006 0.686 0.931
IGHV4–39 0.424 0.993 0.984 0.312 0.459 0.577 0.006 0.806 0.976
IGHV4–4 0.245 0.985 0.986 0.294 0.7 0.767 0.001 0.644 0.961
IGHV4–59 0.308 0.977 0.975 0.236 0.22 0.406 0.003 0.543 0.907
IGHV4–61 0.31 0.992 0.99 0.227 0.125 0.327 0.003 0.76 0.972
IGHV4–b 0.31 0.987 0.985 0.127 0.192 0.461 0.004 0.685 0.953
IGHV5–51 0.791 0.996 0.977 0.599 0.934 0.903 0.065 0.917 0.975
IGHV5–a 0.888 0.997 0.967 0.596 0.938 0.901 0.21 0.975 0.981
HumanVH 6 gene
IGHV6–1 0.041 0.966 0.994 0.214 0.356 0.573 0.008 0.855 0.987
HumanVH 7 genes
IGHV7–41 0.453 0.886 0.869 0.24 0.131 0.264 0.012 0.193 0.601
IGHV7–81 0.893 0.515 0.319 0.522 0.005 0.014 0.26 0.015 0.043

This Article

  1. Genome Res. 9: 1294-1304

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