Paralogous Genes Located Within Duplicated Regions on Chromosomes 16p11–p13, 17q11–q25, and 22q11–q24
| Chromosome 16 | Chromosome 17 | Chromosome 22 | ||||||
| gene | RH map | cytologenetic | gene | RH map | cytologenetic | gene | RH map | cytologenetic |
| ARHGDIG | 19.85 | 16p13.3 | ARHGDIA | 537.27 | 17q25.3 | |||
| CSNK1D | 501.76–539.58 | 17q25 | CSNK1E | 131.36 | 22q12–q13 | |||
| SSTR5 | 25.14 | 16p13.3 | SSTR2 | 460.32 | 17q24 | SSTR3 | 111.72–124.01 | 22q13.1 |
| CACNA1H | 44.93–65.94 | 16p13.3 | CACNA1G | 347.18–351.66 | 17q22 | CACNA1I | 137.86–138.61 | 22q12.3–q13.2 |
| SYNGR3 | 65.01–65.33 | 16p13.3 | SYNGR2 | N.D. | 17qtel | SYNGR1 | 138.19 | 22q13 |
| RPL3L | 65.01 | 16p13.3 | RPL3 | 138.19 | 22q13 | |||
| CREBBP | 62.52–68.90 | 16p13.3 | EP300 | N.D. | 22q13.2 | |||
| SOX9 | 448.88–466.09 | 17q24.3–q25.1 | SOX10 | 115.15 | 22q13 | |||
| GRIN2A | 95.4–100.92 | 16p13.2 | GRIN2C | N.D. | 17q24–q25 | |||
| PMM2 | N.D. | 16p13.3–p13.2 | PMM1 | 126.67–138.78 | 22q13.1 | |||
| TOP3L** | 191.15 | 16p11.2 | TOP3B | N.D. | 22q11 | |||
| CRYM | 191.25–192.97 | 16p13.11–p12.3 | CRYBA1 | N.D. | 17q11.1–q12 | CRYBA4 | 72.13–76.42 | 22q12.1 |
| CRYBB1 | 72.13–76.42 | 22q11.2–q12.1 | ||||||
| CRYBB2 | 72.13–76.42 | 22q11.2–q12.1 | ||||||
| CRYBB3 | 72.13–76.42 | 22q11.2–q12.1 | ||||||
| PRKCB1 | 197–200.56 | 16p11.2 | PRKCA | 421.67 | 17q22–q23.2 | |||
| CACNG3** | 197 | 16p12–13.1 | CACNG5** | 421.16 | 17q24 | CACNG2 | 112 | 22q12–q13 |
| CACNG4** | 421.16 | 17q24 | ||||||
| CACNG1 | 421.16 | 17q24 | ||||||
| TBX6 | N.D. | 16p11.2 | TBX2 | 371.45 | 17q23 | TBX1 | N.D. | 22q11.2 |
| TBX4* | 385.31 | 17q23 | ||||||
| TBRL** | 338.95 | 17q23 | ||||||
| CLTC | 376.31–377.45 | 17q11–qter | CLTCL | N.D. | 22q11.2 | |||
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RH map values refer to 3000 cR on the Genebridge4 (GB4) radiation hybrid mapping panel (Gyapay et al. 1996; Deloukas et al. 1998; GeneMap '98). Cytogenetic locations are from OMIM. (*) Previously identified but not mapped. (**) Novel genes identified in this study. (ARHGDI) Rho gdp-dissociation inhibitor; (CSNK) casein kinase; (SOX) SRY (Sex determining region Y)-box; (SSTR) somatostatin receptor; (SYNGR) synaptogyrin; (RPL3L) ribosomal protein, L3-like; (RPL3) ribosomal protein L3; (CREBBP) CREB-binding protein; (EP300) E1A binding protein p300; (CACN) voltage-gated calcium channel; (GRIN) ionotropic glutamate receptor; (PMM) phosphomannomutase; (TOP) topoisomerase; (CRY) crystallin; (PRKC) protein kinase C; (TBX) T-box transcription factor; (TBR) T-box brain protein; (CLT) clathrin; (N.D.) not determined. New gene symbols were approved by the HUGO/GDB Nomenclature Committee.
