Extreme Reduction of Chromosome-Specific α-Satellite Array Is Unusually Common in Human Chromosome 21

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Figure 8.
Figure 8.

(A) The general organization of α-satellite domains on chromosome 21 (and chromosome 13); (B) proposed model for the formation of low-alphoid centromere by unequal crossing-over caused by a misalignment of the α-satellite arrays between two homologous α21-I/αRI domains (i) and between two nonhomologous α21-I/αRI and α21-II/non-αRI domains on different chromosomes 21 (ii).

This Article

  1. Genome Res. 9: 895-908

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