Extreme Reduction of Chromosome-Specific α-Satellite Array Is Unusually Common in Human Chromosome 21

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Figure 4.
Figure 4.

Combined immunocytochemical and FISH analyses for the detection of CENP-B (A), CENP-C (B), and CENP-E (C) with the αRI probe. The cell line contains two low-αRI chromosomes 21 (arrows). (i) Combined images of centromeric protein signals (red) and the αRI signals (green); (ii) split images of i showing the FITC signals for the αRI domain; (iii) split images of i showing the Texas Red signals for the centromeric proteins. Nuclei and chromosomes are counterstained with DAPI and pseudocolored blue.

This Article

  1. Genome Res. 9: 895-908

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