AAA+: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes

Table 1.

Whole-Genome Analysis of AAA+Proteins

Archaea Bacteria Eukarya
Archaeoglobus Methanobacterium Methanococcus Aquifex Escherichia Synechocystis Bacillus Mycobacterium Saccharomyces Caenorhabditis
AAA+(total) 17 18 15 17 28 20 24 26 ∼50 ∼50
AAA 4 3 2 1 1 5 2 3 21 19
RFC/γ 2 2 2 2 2 2 2 2 6 5
ClpA/B 1 2 2 2 2 2 2
CDC6 1 2 2 2
MCM 1 1 3 6 5
TIP49 1 2 2
ClpX/Y 2 2 1 2 1 1 1
Lon 1 1 1 1 1
MoxR-like 1 1 2 1 3
Mg2+chelatase 1 1 2
Ynv8 1 1 1 1
McrB 1 1
MorR-like 2 1
DnaA 1 2 1 1 1
RuvB 1 1 1 1
NtrC 4 11 5
SpoVJ 1 1
YifB 1 1 1 1
YkxC 2
La-like 1 2 1
Mta-like 2
Dynein 1 2
AGF1 1 1
  • Numbers of proteins in each family per genome are indicated. Families are grouped according to their occurrence among the three divisions of life.

  • Appears to have spread to archaeans and eukaryotes by horizontal transfer from bacteria.

This Article

  1. Genome Res. 9: 27-43

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