Schematic representations of the domain architectures of AAA+proteins. (Znc) 5 cysteine zinc cluster; (vWA) von Willebrand factor A domain; (ACT) novel ligand binding domain; (H) helix–turn–helix DNA-binding domain; (BRCT) BRCA carboxy-terminal domain; (bromo) bromodomain. Domains references can be found at the SMART Web site (Schultz et al. 1998). The yellow box in ORC1 represents a novel uncharacterized domain seen in chromatinic proteins. Coiled–coil regions were predicted using the Coils program (Lupas 1996); signal peptides and transmembrane regions were predicted using Signal-P (Nielsen et al. 1997) and PHD-Tmpred (Rost et al. 1996), respectively.
