Distribution of Protein Folds in the Three Superkingdoms of Life

Table 1.

Upper Limit of 95% Confidence Interval for False-Positive Rate

Fold False-positive rate (%)
β-propeller 2.1
PLP-dependent transferases 2.5
α/β-hydrolase 2.8
SAM-methyltransferases 3.0
Zn-β-lactamases 3.3
Periplasmic-binding II 3.4
Ferredoxin-like 3.7
ATP-pyrophosphatases 4.3
TIM-barrel 5.3
P-loop NTPases 5.6
RNase H-like 5.8
NR-ligand binding 6.1
Rossmann-like 6.2
Protein kinases 6.3
Flavodoxin-like 7.6
Rossmann-fold 9.6
ATP-grasp 17.1
Class II aaRS and biotin synthetases 23.9
  • Abbreviated SCOP 1.35-fold names.

This Article

  1. Genome Res. 9: 17-26

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