Figure 1.
Schematic representation of the duplicated Cdc2L1/2 andMMP21/22 genes linked to D1Z2 on 1p36.3. Shown is the organization of two duplicated genomic segments on human chromosome 1p36.3; each segment contains a Cdc2L and MMP gene (Cdc2L1 and MMP2 or Cdc2L2 andMMP22). Also shown is their transcriptional orientation relative to one another, the mosaic structure of the Cdc2Lgenes (each having 21 exons and 20 introns), their linkage to D1Z2, and their relationship to telomeric and centromeric regions of the short arm of chromosome 1. The various human genomic cosmid, P1 phage, and BAC clones used to construct this detailed map are indicated below the map.
