Overlapping Genomic Sequences: A Treasure Trove of Single-Nucleotide Polymorphisms

Table 1.

Results of Analyzing 68 SNPs Found in 3 Overlapping Clones

Chromosome location Length of overlap (bp) Polymorphisms found SNPs SNPs analyzed Informative SNPs
African– American Caucasian Hispanic populations
3 >2 >1
5p15.2 81,830 20 18 10  6  8  6  6  6  8
8 STSs 3892 bp 60% 80% 60% 60% 60% 80%
7q21–7q22 59,048 97 83 20 14 15 17 12 16 18
13 STSs 6360 bp 70% 75% 85% 60% 80% 90%
13q12–q13 59,739 66 52 38 11  8 11  5 10 16
23 STSs 7720 bp 29% 21% 29% 13% 26% 42%
 Totals 200,617 183 153 68 31 31 34 23 32 42
44 STSs 18172 bp 46% 46% 50% 34% 47% 62%
  • SNPs found among all of the polymorphisms identified in the overlap.

  • SNPs analyzed by determining their frequencies in the population pools, after discarding from consideration polymorphisms found in repetitive regions. The number of STSs and base pairs scanned in the process of analyzing the SNPs are also listed.

  • Number of SNPs (and the proportion among the SNPs analyzed) with allele frequencies of >20% for the minor allele are categorized according to the individual populations studied and the number of populations in which these informative SNPs are found.

This Article

  1. Genome Res. 8: 748-754

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