Genome Scan and Congenic Strains for Blood Pressure QTL Using Dahl Salt-Sensitive Rats

Table 1.

Comparison of Systolic Blood Pressure and Body Weight for LEW and R Male Rats Fed Either 0.2% NaCl or 8% NaCl Diet for 24 Weeks

No. of weeks on diet LEW (no.) R (no.) Two-way ANOVA
0.2% NaCl (8) 8% NaCl (8) 0.2% NaCl (10) 8% NaCl (10)
strain diet interaction
Blood pressure (mmHg)
 4 141 ± 1.8 140 ± 4.4 143 ± 1.9 150 ± 3.5 0.051 0.26 0.24
 8 141 ± 3.3 152 ± 4.5 142 ± 2.2 159 ± 2.0 0.17 <0.001 0.34
16 135 ± 5.1 142 ± 2.6 132 ± 3.1 150 ± 2.3 0.40 <0.001 0.12
24 131 ± 3.3 140 ± 2.5 141 ± 3.2 156 ± 4.0 0.001 0.001 0.43
Body weight (grams)
 4 284 ± 6.2 286 ± 4.4 238 ± 4.7 243 ± 5.5 <0.001 0.48 0.79
 8 375 ± 7.1 352 ± 4.6 313 ± 4.8 309 ± 6.3 <0.001 0.028 0.11
16 455 ± 9.1 409 ± 5.1 379 ± 5.7 365 ± 6.4 <0.001 <0.001 0.029
24 506 ± 12.4 452 ± 5.2 422 ± 5.4 407 ± 5.7 <0.001 <0.001 0.011
  • Means ± s.e. are given; (ANOVA) analysis of variance.

This Article

  1. Genome Res. 8: 711-723

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