Evidence for the Presence of Insulin-Dependent Diabetes-Associated Alleles on the Distal Part of Mouse Chromosome 6

Table 4.

Genotype Distribution for Each Phenotype and Statistics for the Three Gene Intervals of Distal Chromosome 6

Interval Locus Normal (1 + 2) Insulitis (3 + 4) Severe phenotype (5 + 6) χ2 Pvalue
N/N : N/P : P/P N/N : N/P : P/P N/N : N/P : P/P
Sex combined
I D6Mit21–11  75 : 26 : 11 11 :  9 : 1 63 : 28 : 17 1.55 N.S.
II D6Mit11–25 113 : 24 : 11 16 : 11 : 0 77 : 36 : 18 11.39 0.0005
III D6Mit25–26 128 : 25 : 18 20 :  8 : 2 99 : 40 : 15 2.82 N.S.

  • Modification of the polychotomous linkage analysis allowed the NOD/NOD genotypes to be assessed against the pooled NOD/PWK +  PWK/PWK genotypes for each histology class. This is a 1 degree of freedom test. Congenic interval analysis for distal chromosome 6.

  • (NS) Not significant.

This Article

  1. Genome Res. 8: 608-620

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