Evidence for the Presence of Insulin-Dependent Diabetes-Associated Alleles on the Distal Part of Mouse Chromosome 6

Table 2.

Genotype Distribution and Statistics for Distal Chromosome 6 in NOD.PWKchr6 Congenic Animals (N8F1 Generations)

Locus Normal (1 + 2) Insulitis (3 + 4) Severe phenotype (5 + 6) P value
N/N : N/P : P/P N/N : N/P : P/P N/N : N/P : P/P
Combined
D6Mit21  91 : 68 : 28 15 : 13 : 9  83 : 64 : 31 N.S.
D6Mit11 119 : 47 : 19 18 : 17 : 1  97 : 53 : 29 N.S.
D6Mit25 135 : 35 : 20 20 : 14 : 3 105 : 59 : 23 0.005
D6Mit26 136 : 32 : 24 24 :  8 : 5 107 : 49 : 27 0.025

This Article

  1. Genome Res. 8: 608-620

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